血清CK-MB、IL-6、LDH水平联合检测在慢性心力衰竭诊断中的效能  

Efficiency of combined detection of serum CK-MB,IL-6 and LDH levels in diagnosis of chronic heart failure

作　　者：岳磊[1] YUE Lei(Department of Clinical Laboratory of the First Affiliated Hospital of Nanyang Medical College,Nanyang 473003 Henan,China)

机构地区：[1]南阳医学高等专科学校第一附属医院检验科,河南南阳473003

出　　处：《中国民康医学》2024年第11期108-111,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:分析血清肌酸激酶同工酶(CK-MB)、白细胞介素-6(IL-6)、乳酸脱氢酶(LDH)水平联合检测在慢性心力衰竭(CHF)诊断中的效能。方法:选取2021年1月至2023年1月该院收治的83例CHF患者进行横断面研究,设为研究组,依据是否发生主要心血管不良事件将其分为预后不良者18例与预后良好者65例,另选取同期于该院体检的83名健康志愿者作为对照组。比较两组、不同心功能分级及不同预后CHF患者血清CK-MB、IL-6、LDH水平,采用Pearson相关性分析血清CK-MB、IL-6、LDH水平与CHF患者心功能分级的相关性,绘制受试者工作特征(ROC)曲线分析治疗后1个月血清CK-MB、IL-6、LDH水平单项及联合检测诊断CHF患者的效能。结果:研究组血清CK-MB、IL-6、LDH水平均高于对照组,差异有统计学意义(P<0.05);不同心功能分级CHF患者血清CK-MB、IL-6、LDH水平比较,Ⅱ级<Ⅲ级<Ⅳ级,差异均有统计学意义(P<0.05);经Pearson相关性分析结果显示,血清CK-MB、IL-6、LDH水平与CHF患者心功能分级均呈正相关(r>0,P<0.05);治疗后1个月,两组血清CK-MB、IL-6、LDH水平均低于治疗前,但预后不良者高于预后良好者,差异有统计学意义(P<0.05);经ROC曲线分析结果显示,血清CK-MB、IL-6、LDH水平单项及联合检测诊断CHF患者预后不良的曲线下面积分别为0.788、0.769、0.760、0.906,且联合检测诊断CHF患者预后不良的效能高于三者单项检测。结论:血清CK-MB、IL-6、LDH水平联合检测诊断CHF的效能高于三者单项检测。Objective:To analyze efficiency of combined detection of serum creatine kinase isoenzyme(CK-MB),interleukin-6(IL-6)and lactate dehydrogenase(LDH)levels in diagnosis of chronic heart failure(CHF).Methods:A cross-sectional study was conducted on 83 patients with CHF admitted to the hospital from January 2021 to January 2023,and they were set as the study group.According to whether major cardiovascular adverse events occurred,they were divided into 18 patients with poor prognosis and 65 patients with good prognosis.In addition,83 healthy volunteers who underwent physical examination in the hospital during the same period were selected as the control group.The levels of serum CK-MB,IL-6 and LDH were compared between the two groups and among the patients with different cardiac function classifications and different prognosis.Pearson correlation analysis was used to analyze the correlations among the serum CK-MB,IL-6,LDH levels and the cardiac function classification in the CHF patients.The receiver operating characteristic(ROC)curve was drawn to analyze the efficiencies of single and combined detection of serum CK-MB,IL-6 and LDH levels in the diagnosis of the CHF patients 1 month after the treatment.Results:The levels of serum CK-MB,IL-6 and LDH in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The comparison of the levels of serum CK-MB,IL-6 and LDH in the CHF patients with different cardiac function classifications showed that:classification II<classification III<classification IV,and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that the serum CK-MB,IL-6 and LDH levels were positively correlated with the CHF patients cardiac function classification(r>0,P<0.05).One month after the treatment,the levels of serum CK-MB,IL-6 and LDH in the two groups were lower than those before the treatment,those in the patients with poor prognosis were higher than those in the patients with good prognosis,and the diff

关 键 词：慢性心力衰竭 肌酸激酶同工酶 乳酸脱氢酶 白细胞介素-6 检测 诊断 效能 

分 类 号：R541.6[医药卫生—心血管疾病]