血清hs-cTnI、CK-MB、NT-proBNP水平与冠心病患者心肌缺血程度、病情严重程度的相关性  

Correlations among serum hs-cTnI,CK-MB,NT-proBNP levels and myocardial ischemia and severity of patients with coronary heart disease

作　　者：刘瑞 马峥 王京京 LIU Rui;MA Zheng;WANG Jingjing(Department of Clinical Laboratory of Xichuan County People’s Hospital,Nanyang 474450 Henan,China)

机构地区：[1]淅川县人民医院检验科,河南南阳474450

出　　处：《中国民康医学》2024年第11期112-114,125,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:分析血清高敏肌钙蛋白I(hs-cTnI)、肌酸激酶同工酶(CK-MB)、N末端脑钠肽前体(NT-proBNP)水平与冠心病患者心肌缺血程度、病情严重程度的相关性。方法:回顾性分析2020年1月至2023年1月该院收治的136例冠心病患者的临床资料,设为观察组,另选取同期136名健康体检者设为对照组,比较两组血清hs-cTnI、CK-MB、NT-proBNP水平,并采用Gensini评分评估心肌缺血程度,比较不同冠状动脉狭窄程度、病情严重程度冠心病患者血清hs-cTnI、CK-MB、NT-proBNP水平,分析血清hs-cTnI、CKMB、NT-proBNP水平与心肌缺血程度、病情严重程度的相关性。结果:观察组血清hs-cTnI、CK-MB、NT-proBNP水平均高于对照组,差异有统计学意义(P<0.05);不同冠状动脉狭窄程度冠心病患者血清hs-cTnI、CK-MB、NT-proBNP水平,轻度狭窄患者<中度狭窄患者<重度狭窄患者,差异均有统计学意义(P<0.05);不同美国纽约心脏病协会(NYHA)心功能分级冠心病患者血清hs-cTnI、CK-MB、NTproBNP水平,Ⅰ级<Ⅱ级<Ⅲ级<Ⅳ级,差异均有统计学意义(P<0.05);Pearson相关性分析结果显示,血清hs-cTnI、CK-MB、NTproBNP水平与冠心病患者心肌缺血程度、病情严重程度均呈正相关(r>0,P<0.05)。结论:血清hs-cTnI、CK-MB、NT-proBNP水平与冠心病患者心肌缺血程度、病情严重程度均呈正相关。Objective:To analyze correlations among serum high-sensitivity troponin I(hs-cTnI),creatine kinase isoenzyme(CKMB),N-terminal brain natriuretic peptide precursor(NT-proBNP)levels and myocardial ischemia and severity of patients with coronary heart disease.Methods:The clinical data of 136 patients with coronary heart disease admitted to this hospital from January 2020 to January 2023 were retrospectively analyzed and they were set as the observation group;another 136 healthy subjects were selected as the control group.The levels of serum hs-cTnI,CK-MB and NT-proBNP were compared between the two groups.Gensini score was used to evaluate the degree of myocardial ischemia.The levels of serum hs-cTnI,CK-MB and NT-proBNP in the patients with coronary heart disease with different degree of coronary artery stenosis and severity of disease were compared.The correlations among the serum hs-cTnI,CK-MB,NT-proBNP levels and the degree of myocardial ischemia and the severity of the disease were analyzed.Results:The levels of serum hs-cTnI,CK-MB and NT-proBNP in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The comparison of the serum hs-cTnI,CK-MB and NT-proBNP levels in patients with different degrees of coronary artery stenosis showed:the patients with mild stenosis<the patients with moderate stenosis<the patients with severe stenosis,and the differences were statistically significant(P<0.05).The comparison of the serum hs-cTnI,CKMB and NT-proBNP levels in the patients with coronary heart disease with different New York Heart Association(NYHA)cardiac function grades showed:grade I<grade II<grade III<grade IV,and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that the serum hs-cTnI,CK-MB and NT-proBNP levels were positively correlated with the degree of myocardial ischemia and the severity of the disease in the patients with coronary heart disease(r>0,P<0.05).Conclusions:The levels of serum hs-cTnI,CK-MB

关 键 词：冠心病 心肌缺血 高敏肌钙蛋白I 肌酸激酶同工酶 N末端脑钠肽前体 病情严重程度 相关性 

分 类 号：R541.4[医药卫生—心血管疾病]