孟鲁司特钠联合酮替芬治疗小儿喘息性支气管炎的临床效果分析  

Analysis on Clinical Effect of Montelukast Sodium Combined with Ketotifen in Treatment of Pediatric Asthmatic Bron⁃chitis

作　　者：纪洪彬 Ji Hongbin(Department of Internal Medicine,Lingquan Town Health Center,Linyi 276600,Shandong Province,China)

机构地区：[1]岭泉镇卫生院内科,山东临沂276600

出　　处：《中国社区医师》2024年第12期25-27,共3页Chinese Community Doctors

摘　　要：目的:分析孟鲁司特钠联合酮替芬治疗小儿喘息性支气管炎的临床效果。方法:选取2020年12月—2022年12月岭泉镇卫生院收治的喘息性支气管炎患儿68例作为研究对象,采用随机数字表法分为对照组与研究组,各34例。对照组给予孟鲁司特钠治疗,研究组在对照组基础上给予酮替芬治疗。比较两组治疗效果。结果:研究组治疗总有效率高于对照组,差异有统计学意义(P=0.032)。治疗后,两组CD4^(+)、CD4^(+)/CD8^(+)水平高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05)。研究组住院时间短于对照组,咳嗽消失时间、肺部干湿啰音消失时间、喘息消失时间早于对照组,差异有统计学意义(P<0.05)。研究组不良反应总发生率低于对照组,差异有统计学意义(P=0.021)。结论:孟鲁司特钠联合酮替芬治疗小儿喘息性支气管炎的效果显著,能够改善患儿免疫功能,加快症状恢复,使其提前出院,且安全性较好,值得临床应用并予以推广。Objective:To analyze the clinical effect of montelukast sodium combined with ketotifen in the treatment of pediatric asthmatic bronchitis.Methods:A total of 68 children with asthmatic bronchitis admitted to Lingquan Town Health Center from De⁃cember 2020 to December 2022 were selected as the study subjects.They were divided into control group and study group accord⁃ing to random number table method,with 34 cases in each group.The control group was treated with montelukast sodium,while the study group was treated with ketotifen on the basis of the control group.The treatment effects of the two groups were compared.Results:The total effective rate of treatment in the study group was higher than that in the control group,and the difference was statistically significant(P=0.032).After treatment,the levels of CD4^(+) and CD4^(+)/CD8^(+) in the two groups were higher than those be⁃fore treatment,and the levels in the study group were higher than those in the control group,with a statistically significant differ⁃ence(P<0.05).The hospital stay in the study group was shorter than that in the control group,and the disappearance time of cough,lung dry and wet rales,and gasping in the study group were earlier than those in the control group,and the difference was statisti⁃cally significant(P<0.05).The total incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant(P=0.021).Conclusion:The montelukast sodium combined with ketotifen has significant effects in treatment of pediatric asthmatic bronchitis,and can improve the immune function of children,accelerate the recovery of symptoms,and achieve early discharge with good safety,which is worthy of clinical application and promotion.

关 键 词：孟鲁司特钠 酮替芬 小儿 喘息性支气管炎 安全性 

分 类 号：R725.6[医药卫生—儿科]