环磷酸腺苷在大面积烧伤患者全身麻醉手术中的肝保护作用分析  

Hepatoprotective Effects of Cyclic Adenosine Monophosphate in Patients with Extensive Burns During General Anesthesia Surgery

作　　者：任玲[1] 张丹妮[1] 齐小冰[1] 贾军乐[1] 支小军[1] Ren Ling;Zhang Danni;Qi Xiaobing;Jia Junle;Zhi Xiaojun(Inner Mongolia Baogang Hospital,Baotou 014010,Inner Mongolia Autonomous Region,China)

机构地区：[1]内蒙古包钢医院,内蒙古自治区包头014010

出　　处：《中国社区医师》2024年第12期31-33,共3页Chinese Community Doctors

基　　金：2022年度自治区卫生健康科技计划项目任务书(编号:202201514)。

摘　　要：目的:分析环磷酸腺苷(cAMP)在大面积烧伤患者全身麻醉手术中的肝保护作用。方法:选取2022年1月—2024年1月内蒙古包钢医院收治的大面积烧伤患者60例作为研究对象,采用单双号法随机分为对照组与观察组,各30例。两组均给予气管插管全身麻醉,观察组给予cAMP。比较两组肝功能指标及麻醉效果。结果:手术开始后5 min、手术开始后60 min、手术开始后90 min、手术开始后120 min,两组外周血丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、总胆红素、间接胆红素水平高于治疗前,但观察组低于对照组,差异有统计学意义(P<0.05)。观察组麻醉苏醒时间、住院时间短于对照组,差异有统计学意义(P<0.05)。结论:cAMP在大面积烧伤患者全身麻醉手术中的肝保护作用显著,患者术中血清肝功能指标稳定,麻醉及术后恢复快。Objective:To analyze the hepatoprotective effect of cyclic adenosine monophosphate(cAMP)in patients with extensive burns during general anesthesia surgery.Methods:A total of 60 patients with with extensive burns admitted to Inner Mongolia Baogang Hospital from January 2022 to January 2024 were selected as the study subjects.These patients were randomly divided into control group and observation group by odd-even number method,with 30 cases in each group.Both groups were given tracheal intubation and general anesthesia.The observation group was treated with cAMP.Liver function indicators and anesthesia effect were compared between two groups.Results:At 5 min,60 min,90 min,120 min after the surgery initiates,the levels of peripheral blood alanine aminotransferase,aspartate aminotransferase,total bilirubin,and indirect bilirubin in the two groups were higher than those before treatment,but the levels in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The time of recovery from anesthesia and the length of hospital stay in the observation group were shorter than those in the control group,and the difference was statistically significant(P<0.05).Conclusion:cAMP has a significant hepatoprotective effect in patients with extensive burns during general anesthesia surgery,and the serum liver function indicators are stable during surgery,and the anesthesia and postoperative recovery are fast.

关 键 词：大面积烧伤 环磷酸腺苷 肝功能 麻醉苏醒 

分 类 号：R641[医药卫生—外科学]