血清淀粉样蛋白A、白细胞介素-6及T淋巴细胞亚群相关指标在系统性红斑狼疮活动期的表达水平分析  

Analysis of the Expression Levels of Serum Amyloid A,Interleukin-6 and T-lymphocyte Subpopulation-related Indicators in the Active Phase of Systemic Lupus Erythematosus

作　　者：邹光美 黄朝任 杨小兰[1] 吴博文[1] Zou Guangmei;Huang Chaoren;Yang Xiaolan;Wu Bowen(The First People's Hospital of Yulin,Yulin 537000,Guangxi Zhuang Autonomous Region,China;Traditional Chinese Medicine Hospital Of YuLin,Yulin 537000,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]玉林市第一人民医院,广西壮族自治区玉林537000 [2]玉林市中医医院,广西壮族自治区玉林537000

出　　处：《中国社区医师》2024年第12期94-96,共3页Chinese Community Doctors

基　　金：玉林市科学研究与技术开发计划课题(编号:玉市科20204402);广西壮族自治区卫生健康委员会自筹经费科研课题(编号:Z20211083)。

摘　　要：目的:分析血清淀粉样蛋白A(SAA)、白细胞介素-6(IL-6)及T淋巴细胞亚群相关指标在系统性红斑狼疮(SLE)活动期的表达水平。方法:选取2020年10月—2023年5月玉林市第一人民医院收治的SLE患者200例作为研究对象,根据SLE活动指数积分表评分分为SLE稳定期组与SLE活动期组,各100例,另选取同期于玉林市第一人民医院进行健康体检的健康人100例作为对照组。检测不同人群SAA、IL-6及T淋巴细胞亚群相关指标水平。结果:SLE稳定期组及SLE活动期组CD3%、CD8%、SAA、IL-6水平均高于对照组,SLE稳定期组SAA、IL-6水平低于SLE活动期组,SLE稳定期组CD4%高于对照组与SLE活动期组,差异有统计学意义(P<0.05)。SLE稳定期组及SLE活动期组CD3^(+)、CD4^(+)、CD8^(+)均小于对照组,且SLE活动期组CD3^(+)、CD4^(+)、CD8^(+)均小于SLE稳定期组,差异有统计学意义(P<0.05)。结论:SAA、IL-6及T淋巴细胞亚群相关指标在SLE患者中均有异常改变,SLE患者活动期T淋巴细胞亚群绝对计数低于稳定期患者,对于SLE的临床诊治具有一定参考价值。Objective:To analyze the expression levels of serum amyloid A(SAA),interleukin-6(IL-6)and T-lymphocyte subpopulation-related indicators in the active phase of systemic lupus erythematosus(SLE).Methods:Two hundred SLE patients admitted to Yulin First People's Hospital from October 2020 to May 2023 were selected as study subjects.According to the score of SLE activity index score table,they were divided into SLE stable stage group and SLE active stage group,one hundred cases each,and another 100 cases of healthy people who underwent health checkups in The First People's Hospital of Yulin during the same period were selected as the control group.The levels of SAA,IL-6 and T-lymphocyte subpopulation-related indexes were detected in different groups.Results:The levels of CD3%,CD8%,SAA and IL-6 were higher in the SLE stable stage group and the SLE active stage group than in the control group;the levels of SAA and IL-6 in the SLE stable stage group were lower than those in the SLE active stage group,and the CD4%in the SLE stable stage group was higher than those in the control group and the SLE active stage group,and the difference was statistically significant(P<0.05);CD3^(+),CD4^(+)and CD8^(+)were smaller in SLE stable stage group and SLE active stage group than control group,and CD3^(+),CD4^(+)and CD8^(+)were smaller in SLE active stage group than SLE stable stage group,and the difference was statistically significant(P<0.05).Conclusion:SAA,IL-6 and Tlymphocyte subpopulation-related indexes were abnormally altered in SLE patients,and the absolute counts of T-lymphocyte subpopulations in SLE patients with active stage were lower than those in stable stage,which is of certain reference value for the clinical diagnosis and treatment of SLE.

关 键 词：系统性红斑狼疮 血清淀粉样蛋白A 白细胞介素-6 T淋巴细胞亚群 

分 类 号：R446[医药卫生—诊断学]