益肾补骨汤联合常规西药对绝经后脊柱压缩性骨折患者术后愈合效果和腰椎功能的影响  

Effect of Yishen Bugu Decoction(益肾补骨汤)Combined with Conventional Western Medicine on Postoperative Healing and Lumbar Function in Postmenopausal Patients with Spinal Compression Fractures

作　　者：陈珮珮 白彬彬 孙伊凡 CHEN Peipei;BAI Binbin;SUN Yifan(Orthopedics Department,Wenzhou Hospital of Traditional Chinese Medicine,Wenzhou 325000,Zhejiang,China)

机构地区：[1]温州市中医院骨科,浙江温州325000

出　　处：《辽宁中医杂志》2024年第6期62-66,共5页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的探究益肾补骨汤联合常规西药对绝经后脊柱压缩性骨折患者术后愈合效果和腰椎功能的影响。方法将该院2021年5月—2022年5月收治的110例绝经后脊柱压缩性骨折患者依据入院建档单双号分为对照组(55例)及观察组(55例)。对照组予以常规西药治疗,观察组在此基础上联合益肾补骨汤治疗,两组均连续治疗1个疗程后观察效果。治疗前后采用视觉模拟评分法(visual analog scale,VAS)量表及数字评分(numerical rating scale,NRS)量表评价两组疼痛情况,采用日本骨科协会腰痛评价表(Japanese Orthopaedic Association Low Back Pain Assessment,JOA)及Oswestry功能障碍指数(Oswestry disability index,ODI)评价两组的腰椎功能变化;比较两组治疗前后的骨代谢水平,并评价两组的术后愈合效果及并发症情况。结果治疗后两组VAS、NRS评分均较降低,且观察组低于对照组(P<0.05);治疗后两组JOA评分升高,ODI评分降低,且观察组JOA评分高于对照组,ODI评分低于对照组(P<0.05);治疗后,两组血清总Ⅰ型胶原氨基端延长肽(total type I collagen amino-terminal elongation peptide,T-PINP)、N-骨钙素(N-terminal osteocalcin,N-MID)水平变化不明显,β-Ⅰ型胶原交联C端肽(type I collagen cross-linked C-terminal peptide,β-CTX)水平低于治疗前,且观察组β-CTX水平显著低于对照组(P<0.05);术后观察组的骨折愈合效果明显优于对照组(P<0.05);两组术后并发症比较差异无统计学意义(P>0.05)。结论益肾补骨汤联合常规西药对绝经后脊柱压缩性骨折患者效果显著,能有效缓解患者的术后疼痛,改善患者腰椎功能,降低骨代谢水平,促进骨折愈合,且无明显的并发症,安全性高。Objective To explore the effect of Yishen Bugu Decoction(益肾补骨汤)combined with conventional western medicine on postoperative healing and lumbar function in postmenopausal patients with spinal compression fractures.Methods A total of 110 patients with postmenopausal spinal compression fractures admitted to the hospital from May 2021 to May 2022 were divided into the control group(55 cases)and the observation group(55 cases)according to the odd and even numbers of the admission files.The control group was treated with conventional western medicine,and the observation group was treated with Yishen Bugu Decoction on this basis.Before and after treatment,the visual analogue scale(VAS)and numerical rating scales(NRS)were used to evaluate the pain in the two groups,and the Japanese orthopaedic association low back pain assessment(JOA)and Oswestry disability index(ODI)were used to evaluate the lumbar spine function of the two groups.The bone metabolism levels of the two groups before and after treatment were compared,and the postoperative healing effect and complications of the two groups were evaluated.Results After treatment,the VAS and NRS scores of the two groups were decreased,and the scores of the observation group were lower than those of the control group(P<0.05).After treatment,the JOA score in the two groups increased,and the ODI score decreased,and the JOA score in the observation group was higher than that in the control group,and the ODI score in the observation group was lower than that in the control group(P<0.05).After treatment,the serum levels of total type I collagen amino-terminal elongation peptide(T-PINP)and N-terminal osteocalcin(N-MID)in the two groups did not change significantly.The level of type I collagen cross-linked C-terminal peptide(β-CTX)was lower than that before treatment,and the level ofβ-CTX in the observation group was significantly lower than that in the control group(P<0.05).The fracture healing effect of the observation group was significantly better than that of the co

关 键 词：绝经妇女 脊柱压缩性骨折 益肾补骨汤 疼痛 腰椎功能 愈合效果 

分 类 号：R274[医药卫生—中医骨伤科学]