人参白茅根汤联合康复新液对肛瘘术后切口愈合效果及对血清TNF-α、IL-1β和IL-6水平的影响  

Effects of Renseng Baimaogen Decoction(人参白茅根汤)Combined with Fufuxin Fluid(康复新液)on Wound Healing after Anal Fistula Operation and Serum Levels of TNF-α,IL-1βand IL-6

作　　者：李剑 吴洪 赵红波 LI Jian;WU Hong;ZHAO Hongbo(Nanchong Central Hospital Anorectal Department of Integrated Traditional and Western Medicine,Nanchong 637000,Sichuan,China)

机构地区：[1]南充市中心医院中西医结合肛肠科,四川南充637000

出　　处：《辽宁中医杂志》2024年第6期66-69,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：四川省中医药管理局科研项目(2018LC045)。

摘　　要：目的探讨人参白茅根汤联合康复新液对肛瘘术后切口愈合的效果及对血清肿瘤坏死因子(tumor necrosis factor-α,TNF-α)、白细胞介素-1β(interleukin-1β,IL-1β)和白细胞介素-6(interleukin-6,IL-6)水平影响。方法选取南充市中心医院收治的肛瘘患者124例,患者均行肛瘘切开挂线术,随机分为对照组(64例,康复新液)和观察组(60例,人参白茅根汤联合康复新液),两组持续治疗10 d,对比两组临床疗效、创面愈合时间和创面面积、临床症状评分、血清TNF-α、IL-6和IL-1β水平及血清成纤维细胞生长因子-1(fibroblast growth factor-1,FGF-1)、血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)及创面表皮生长因子(wound epidermal growth factor,EGF)浓度水平的改变情况。结果观察组总有效率更高(P<0.05);观察组创面愈合时间和术后7 d和10 d创面面积治疗后较对照组更低(P<0.05),而两组术后2 d的创面面积比较差异无统计学意义(P>0.05);两组临床症状的评分治疗前比较差异无统计学意义(P>0.05);术后疼痛、创面分泌物的评分以及创缘水肿的评分方面,两组治疗后均下降明显(P<0.05);且观察组的下降程度更为明显(P<0.05);治疗前两组血清内的IL-6、TNF-α和IL-1β浓度水平比较差异无统计学意义(P>0.05);而两组治疗后血清内的IL-6、TNF-α浓度水平下降明显,而血清内的IL-1β浓度水平升高(P<0.05);且观察组下降更为明显(P<0.05);两组治疗前血清内的FGF-1、VEGF和EGF浓度水平比较差异无统计学意义(P>0.05);治疗后两组血清FGF-1、VEGF和EGF水平显著升高(P<0.05);且观察组上升更为明显(P<0.05)。结论术后肛瘘病人实施康复新液结合人参白茅根汤治疗具有较好的疗效,可改善血清TNF-α、IL-1β和IL-6水平。Objective To investigate the effect of Renseng Baimaogen Decoction(人参白茅根汤)combined with Fufuxin Fluid(康复新液)on wound healing after anal fistula operation and the effect on serum levels of tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β)and interleukin-6(IL-6).Methods A total of 124 patients with anal fistula admitted to Nanchong Central Hospital were chosen and randomly divided into observation group(60 cases,Rensen Baimaogen Decoction combined with Kangfuxin Fluid)and control group(64 cases,Kangfuxin Fluid).The two groups were treated continuously for 10 days.Clinical efficacy,wound healing time and wound area,clinical symptom score,serum levels of TNF-α,IL-6 and IL-1β,and serum levels of fibroblast growth factor-1(FGF-1),vascular endothelial growth factor(VEGF)and wound epidermal growth factor(EGF)were compared between two groups.Results After treatment,the total effective rate of the observation group was higher(P<0.05).The wound healing time and wound area at 7 d and 10 d after operation in the observation group were obvious lower than that in the control group(P<0.05),and there was no obvious difference in wound area at 2 d after operation between two groups(P>0.05).Before treatment,there was no obvious difference in clinical symptom scores between two groups(P>0.05).After treatment,wound secretion score,postoperative pain score and wound edema score in two groups were obviously decreased(P<0.05).And the reduction in the observation group was more obvious(P<0.05).Before treatment,the serum levels of TNF-α,IL-6 and IL-1βwere not different between two groups(P>0.05).After treatment,the serum levels of TNF-αand IL-6 were obviously decreased,while the serum level of IL-1βwas obvious increased(P<0.05).And that of the observation group was obviously decreased(P<0.05).There were no obvious differences in serum levels of VEGF,FGF-1 or EGF between two groups before treatment(P>0.05).After treatment,the serum levels of VEGF,FGF-1 and EGF in two groups were obviously increased(P<0.05).A

关 键 词：人参白茅根汤 康复新液 肛瘘术后 切口愈合 血清TNF-α、IL-1β和IL-6水平 

分 类 号：R266[医药卫生—中医外科学]