宣壅清肺汤治疗老年重症肺炎临床观察  

Clinical Observation of Xuanyong Qingfei Decoction(宣壅清肺汤)Treating Senile Severe Pneumonia

作　　者：杨爱琴[1] 韩晓燕[1] 陈洁 YANG Aiqin;HAN Xiaoyan;CHEN Jie(Hospital of Yan′an University,Yan′an 716000,Shaanxi,China;Xijing Hospital,Air Force Medical University,Xi′an 710000,Shaanxi,China)

机构地区：[1]延安大学校医院,陕西延安716000 [2]空军军医大学西京医院,陕西西安710000

出　　处：《辽宁中医杂志》2024年第6期74-77,共4页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的观察宣壅清肺汤治疗老年重症肺炎的临床效果。方法2021年1月—2022年1月医院收治的老年重症肺炎患者120例随机分为抗生素治疗组(60例)和联合宣壅清肺治疗组(60例)。联合宣壅清肺治疗组采用常规治疗联合宣壅清肺汤治疗,抗生素治疗组进行常规治疗,两组均治疗2周。统计两组治疗2周后的疗效,比较两组治疗前和治疗2周后中医证候积分、血清炎性因子水平、肺功能、血气指标及病情情况。结果治疗2周后,联合宣壅清肺治疗组总有效率为93.33%(56/60),高于抗生素治疗组[80.00%(48/60),P<0.05]。治疗2周后与治疗前比较,两组咳嗽、发热、痰黄或黏稠带血、气喘息粗、胸闷烦躁、口干渴评分及血清可溶性细胞间黏附分子-1(soluble intercellular adhesion molecule-1,sICAM-1)、干扰素-γ(interferon-γ,IFN-γ)、血小板活化因子(platelet activating factor,PAF)、高迁移率族蛋白B1(high mobility group protein B1,HMGB1)水平、二氧化碳分压(carbon dioxide partial pressure,PaCO_(2))、急性生理学及慢性健康状况(scores of acute physiology and chronic health status,APACHEⅡ)、全身炎症反应综合征(systemic inflammatory response syndrome,SIRS)、临床肺部感染(clinical pulmonary infection,CPIS)、肺炎严重指数(pneumonia severity index,PSI)评分降低,联合宣壅清肺治疗组低于抗生素治疗组(P<0.05);两组第1秒用力呼气容积(first second forced expiratory volume,FEV1)、用力肺活量(forced vital capacity,FVC)、氧分压(oxygen partial pressure,PaO_(2))升高,联合宣壅清肺治疗组高于抗生素治疗组(P<0.05)。结论宣壅清肺汤可改善老年重症肺炎患者中医证候,通过降低机体炎症反应提高其肺功能及血气指标,疗效较好。Objective To observe the clinical effect of Xuanyong Qingfei Decoction(宣壅清肺汤)treating senile severe pneumonia.Methods From January 2021 to January 2022,120 elderly patients with severe pneumonia admitted to the hospital were randomly divided into antibiotic treatment group(60 cases)and combined with Xuanyong Qingfei Decoction treatment group(60 cases).The combined with Xuanyong Qingfei Decoction treatment group was treated with conventional treatment combined with Xuanyong Qingfei Decoction,and the antibiotic treatment group was treated with conventional treatment.Both groups were treated for 2 weeks.The curative effect of the two groups after 2 weeks of treatment was counted,and the scores of traditional Chinese medicine symptoms,serum inflammatory factors,lung function,blood gas indexes and disease condition were compared before and after 2 weeks of treatment.Results After 2 weeks of treatment,the total effective rate of the combined with Xuanyong Qingfei Decoction treatment group was 93.33%(56/60),which was significantly higher than that of the antibiotic treatment group[80.00%(48/60),P<0.05].After 2 weeks of treatment compared with those before treatment,the scores of cough,fever,yellow or sticky sputum with blood,wheezing,chest tightness and irritability,mouth thirst score,levels of serum soluble intercellular adhesion molecule-1(sICAM-1),interferon-γ(IFN-γ),platelet activating factor(PAF),high mobility group protein B1(HMGB1),carbon dioxide partial pressure(PaCO_(2)),scores of acute physiology and chronic health status(APACHEⅡ),systemic inflammatory response syndrome(SIRS),clinical pulmonary infection(CPIS)and pneumonia severity index(PSI)in the two groups decreased,and those in the combined with Xuanyong Qingfei Decoction treatment group were lower than those of the antibiotic treatment group(P<0.05).The values of first second forced expiratory volume(FEV1)and forced vital capacity(FVC)and oxygen partial pressure(PaO_(2))of the two groups increased,and the combined with Xuanyong Qingfei treat

关 键 词：重症肺炎 老年 宣壅清肺汤 哌拉西林舒巴坦 临床效果 

分 类 号：R256.1[医药卫生—中医内科学]