加味逍遥丸联合坤宝丸治疗围绝经期综合征女性失眠疗效观察  

Effect of Jiawei Xiaoyao Pill(加味逍遥丸)and Kunbao Pill(坤宝丸)on Insomnia in Women with Perimenopausal Syndrome

作　　者：郭建华 宫月 李玉华 孙淑红 GUO Jianhua;GONG Yue;LI Yuhua;SUN Shuhong(Chengde Maternal and Child Health Hospital,Chengde 067000,Hebei,China)

机构地区：[1]承德市妇幼保健院,河北承德067000

出　　处：《辽宁中医杂志》2024年第6期89-92,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：河北省中医药类科学研究课题计划项目(2023189)。

摘　　要：目的探讨加味逍遥丸联合坤宝丸对围绝经期综合征女性失眠疗效观察。方法选择该院治疗的围绝经期综合征患者121例,按入院顺序进行分组,单号为西药常规治疗组61例,双号为加味逍遥丸+坤宝丸组60例,比较两组治疗效果;比较两组用药前后匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)评分、生活质量予以评定;测定用药前后两组血清性激素水平、睡眠潜伏期(sleep latency,SL)、觉醒次数(arousal times,AT)、总睡眠时间(total sleep time,TST)变化及不良反应发生情况。结果西药常规治疗组总有效率为80.32%(49/61),加味逍遥丸+坤宝丸组总有效率为91.67%(55/60),组间比较差异有统计学意义(P<0.05);两组用药前PSQI、生活质量分值比较差异无统计学意义(P>0.05),两组PSQI评分分值均低于治疗前,生活质量分值高于治疗前(P<0.05),且与西药常规治疗组用药后比较,加味逍遥丸+坤宝丸组PSQI分值降低,生活质量分值上升(P<0.05);两组用药前性激素值比较差异无统计学意义(P>0.05),用药后卵泡刺激素(follicle stimulating hormone,FSH)、黄体生成素(luteinizing hormone,LH)值增加,雌二醇(estradiol,E2)值减少,且西药常规治疗组FSH、LH值较加味逍遥丸+坤宝丸组低,E2值较加味逍遥丸+坤宝丸组高(P<0.05)。两组干预前SL、AT、TST值比较差异无统计学意义(P>0.05),与加味逍遥丸+坤宝丸组用药后比较,西药常规治疗组SL值降低,AT值下降,TST值有明显的上升(P<0.05)。西药常规治疗组患者用药后共有30例出现不良反应、加味逍遥丸+坤宝丸组患者用药后共有10例出现不良反应,西药常规治疗组患者不良反应发生概率[49.18%(30/61)]高于加味逍遥丸+坤宝丸组[16.67%(10/60)],组间比较差异有统计学意义(P<0.05)。结论加味逍遥丸联合坤宝丸治疗围绝经期综合征效果好于西药,能显著改善患者睡眠质量,且不良反应较少。Objective To investigate the effect of Jiawei Xiaoyao Pill(加味逍遥丸)and Kunbao Pill(坤宝丸)on insomnia in women with perimenopausal syndrome.Methods A total of 121 patients with perimenopausal syndrome treated in the hospital were selected and grouped according to the order of admission,61 patients with the single number were in the conventional western medicine group and 60 patients with double number were in the Jiawei Xiaoyao Pill+Kunbao Pill group.The treatment effect,Pittsburgh sleep quality index(PSQI)score and quality of life of the two groups were evaluated before and after administration.The serum levels of sex hormone levels,the changes of sleep latency(SL),arousal times(AT),total sleep time(TST)and adverse reactions in two groups were measured before and after administration.Results The total effective rate of the conventional western medicine group was 80.32%(49/61)and that of the Jiawei Xiaoyao Pill+Kunbao Pill group was 91.67%(55/60).The comparison between the groups was significant(P<0.05).The comparison of the PSQI and quality of life scores before treatment in two groups were not significant(P>0.05).PSQI scores of two groups after treatment were lower than those before treatment,the quality of life score was higher than that before treatment(P<0.05),and compared with those of the conventional western medicine group after treatment,the PSQI score of the Jiawei Xiaoyao Pill+Kunbao Pill group decreased,and the quality of life score increased(P<0.05).The sex hormone comparison between the two groups was not significant(P>0.05)before treatment.The levels of follicle stimulating hormone(FSH)and luteinizing hormone(LH)increased and the estradiol(E2)level decreased after treatment in two groups.The levels of FSH and LH level in the conventional western medicine group were lower than those of the Jiawei Xiaoyao Pill+Kunbao Pill group and the E2 level in the conventional western medicine group was higher than that in the Jiawei Xiaoyao Pill+Kunbao Pill group(P<0.05).The values of SL,AT and TST of

关 键 词：围绝经期综合征 加味逍遥丸 坤宝丸 失眠 

分 类 号：R271.116[医药卫生—中医妇科学]