二至天癸方改善高龄女性体外受精-胚胎移植结局的Meta分析  

Erzhi Tiangui Prescription improving the outcome of in vitro fertilization-embryo transfer in elderly women:a Meta-analysis

作　　者：贾志诚 李永谦 王培璇 连方[3] 郭颖 JIA Zhicheng;LI Yongqian;WANG Peixuan;LIAN Fang;GUO Ying(The First Clinical College,Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong,China;College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong,China;Reproductive and Genetic Center of Integrative Medicine,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250011,Shandong,China)

机构地区：[1]山东中医药大学第一临床医学院,济南250014 [2]山东中医药大学中医学院,济南250014 [3]山东中医药大学附属医院生殖与遗传科,济南250011

出　　处：《中国性科学》2024年第5期113-118,共6页Chinese Journal of Human Sexuality

基　　金：国家自然科学基金项目(82374505);山东省自然科学基金项目(ZR2023MH219);山东省“泰山青年学者”计划项目(tsqn202211353);济南市科技计划项目(202225005)。

摘　　要：目的系统性评价二至天癸方改善高龄女性体外受精-胚胎移植(IVF-ET)结局的有效性和安全性,为高龄女性IVF-ET的临床用药提供循证医学依据。方法检索中国知网、万方、维普、PubMed、Web of Science、Cochrane Library数据库中有关二至天癸方改善高龄女性IVF-ET结局的随机对照试验,检索时间为建库至2022年5月1日。采用RevMan 5.3软件对纳入文献研究进行Meta分析。结果最终纳入符合标准的文献共9篇,共677例患者。Meta分析结果显示,二至天癸方显著改善了行IVF-ET高龄女性的临床妊娠率、优质胚胎率、获卵数,且显著减少了促性腺激素(Gn)使用剂量(P<0.05)。试验组的2PN受精率虽优于对照组,但差异无统计学意义(P=0.06)。结论二至天癸方在改善高龄女性IVF-ET结局方面效果良好,是高龄女性IVF-ET临床用药中较有前景的中药方剂。Objective To systematically evaluate the efficacy and safety of Erzhi Tiangui Prescription on the outcome of in vitro fertilization-embryo transfer(IVF-ET)in elderly women,and provide evidence-based medical evidence for the clinical use of IVF-ET in elderly women.Methods The randomized controlled trial of Erzhi Tiangui Prescription improving the outcome of in vitro fertilization-embryo transfer in elderly women were searched from CNKI,Wanfang,VIP,PubMed,Web of Science,Cochrane Library database,with the search period from establishment to May 1,2022.A Meta-analysis was performed by using RevMan 5.3 software.Results Finally,a total of 9 literatures meeting the criteria were included,involving 677 patients.The results of the Meta-analysis indicated that Erzhi Tiangui Prescription significantly improved clinical pregnancy rate,good quality embryos rate,retrieved oocytes number in elderly women with IVF-ET,and also significantly decreases the dosage of gonadotrophin(P<0.05).However,the two-pronuclear(2PN)fertilization rate of the experiment group was better than control group,but the difference was not statistically significant(P=0.06).Conclusions Erzhi Tiangui Prescription has good effect on improving the outcome of IVF-ET in elderly women,and is a promising traditional Chinese medicine in the clinical use for IVF-ET in elderly women.

关 键 词：二至天癸方 高龄女性 不孕症 体外受精-胚胎移植 

分 类 号：R275[医药卫生—中医皮科]