加味千金地肤子汤治疗肾虚湿热型慢性前列腺炎/慢性盆腔疼痛综合征合并弱精症的临床观察  

Clinical observation on the treatment of chronic prostatitis/chronic pelvic pain syndrome combined with asthenozoospermia of kidney deficiency damp heat type with Jiawei Qianjin Difuzi Tang

作　　者：龙广益 刘付国琛 周武林 曾志宇 陈和亮 李静 LONG Guangyi;LIU Fuguochen;ZHOU Wulin;ZENG Zhiyu;CHEN Heliang;LI Jing(Department of Andrology,Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine,Zhuhai 519000,Guangdong,China)

机构地区：[1]珠海市中西医结合医院男科,广东珠海519000

出　　处：《中国性科学》2024年第5期135-138,共4页Chinese Journal of Human Sexuality

基　　金：珠海市科技计划医疗卫生项目(ZH2202200052HJL)。

摘　　要：目的探讨采用加味千金地肤子汤治疗慢性前列腺炎/慢性盆腔疼痛综合征(CP/CPPS)合并弱精症的临床疗效。方法选取2020年7月至2021年12月于珠海市中西医结合医院就诊的86例肾虚湿热型CP/CPPS合并弱精症患者作为研究对象,随机分为治疗组(n=44)和对照组(n=42)。对照组给予西药常规治疗,治疗组在对照组的基础上给予加味千金地肤子汤治疗。比较两组临床疗效、治疗前后的中医证候评分及精液质量。结果经12周治疗后,治疗组总体有效率(88.6%)高于对照组(66.7%),美国国立卫生研究院慢性前列腺炎症状指数(NIH-CPSI)评分、中医证候评分、精子DNA碎片率(DFI)显著低于对照组,平均尿流率(AFR)、最大尿流率(MRF)、精子总活力(PR+NP)、精子顶体酶活性显著高于对照组(P<0.05)。结论加味千金地肤子汤联合西药治疗可改善肾虚湿热型CP/CPPS合并弱精症患者的排尿困难、骨盆疼痛、性功能及精子活力下降等症状。Objective To discuss the clinical efficacy of Jiawei Qianjin Difuzi Tang in the treatment of chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS)combined with asthenozoospermia.Methods A total of 86 patients with kidney deficiency and damp heat type CP/CPPS combined with asthenozoospermia admitted to Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine were selected as study objects.They were randomly divided into an experimental group(n=44)and a control group(n=42).The control group was treated with conventional western medicine,while the experimental group was treated with Jiawei Qianjin Difuzi Tang on the basis of the control group.The clinical efficacy,traditional Chinese medicine(TCM)syndrome score and semen quality of the two groups were compared before and after treatment.Results After 12 weeks of treatment,the overall effective rate of the experimental group(88.6%)was higher than that of the control group(66.7%).The national institutes of health chronic prostatitis symptom index(NIH-CPSI)score,TCM syndrome score,and sperm DNA fragment index(DFI)level of the experimental group were significantly lower than those of the control group.Average urine flow rate(AFR),maximum urine flow rate(MFR),progressive motility+non-progressive motility(PR+NP),and sperm acrosin activity were significantly higher than those of the control group(P<0.05).Conclusions Jiawei Qianjin Difuzi Tang combined with western medicine can improve the symptoms of dysuria,pelvic pain,sexual function and sperm motility decline in patients with kidney deficiency damp heat type CP/CPPS combined with asthenozoospermia.

关 键 词：肾虚湿热 加味千金地肤子汤 慢性前列腺炎/慢性盆腔疼痛综合征 慢性前列腺炎症状指数评分表 弱精症 中医证候评分 尿流动力学 精子质量 

分 类 号：R697[医药卫生—泌尿科学]