半胱氨酸蛋白酶抑制剂C与糖尿病肾病的相关性  

Correlation between cystatin C and diabetic kidney disease

作　　者：梁园芳 张端倪 闫妮 惠蓉[2] 李晓燕[1] 苏亚[3] LIANG Yuanfang;ZHANG Duanni;YAN Ni;HUI Rong;LI Xiaoyan;SU Ya(Department of Rheumatology and Immunology,Shaanxi Provincial People’s Hospital,Shaanxi Province,Xi’an 710068,China;the Third Clinical Management Department,Shaanxi Provincial People’s Hospital,Shaanxi Province,Xi’an 710068,China;Department of Endocrinology,Shaanxi Provincial People’s Hospital,Shaanxi Province,Xi’an 710068,China)

机构地区：[1]陕西省人民医院风湿免疫科,陕西西安710068 [2]陕西省人民医院第三临床管理部,陕西西安710068 [3]陕西省人民医院内分泌科,陕西西安710068

出　　处：《中国医药导报》2024年第12期64-67,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(82100830);陕西省重点研发计划项目(2022SF-007)。

摘　　要：目的探讨半胱氨酸蛋白酶抑制剂C(Cys C)与糖尿病肾病(DKD)的相关性。方法收集2019年1月至12月陕西省人民医院内分泌科住院的122例2型糖尿病(T2DM)患者的临床资料,按尿白蛋白与肌酐比值(UACR)分为单纯糖尿病(DM)组(UACR<30 mg/g,89例)、DKD组(UACR≥30 mg/g,33例)。比较两组临床资料,采用logistic回归分析T2DM患者发生DKD的危险因素,绘制受试者操作特征(ROC)曲线评价Cys C对DKD的预测价值。结果DKD组收缩压、碱性磷酸酶、总蛋白、球蛋白、血清肌酐、尿微量白蛋白、尿α_(1)微球蛋白、UACR、Cys C均高于单纯DM组,病程长于单纯DM组(P<0.05)。logistic回归分析显示,Cys C是DKD的危险因素(OR=28.369,95%CI:1.208~666.129,P=0.038)。ROC曲线分析显示,Cys C预测DKD的曲线下面积为0.757(P<0.05)。结论Cys C与T2DM合并DKD密切相关,检测Cys C可用于评估DKD病情进展。Objective To investigate the correlation between cystatin C(Cys C) and diabetic kidney disease(DKD).Methods Clinical data of 122 patients with type 2 diabetes mellitus(T2DM) admitted to the Department of Endocrinology of Shaanxi Provincial People's Hospital from January to December 2019 was collected.According to the urinary albumin to creatinine ratio(UACR),patients were divided into DM group(UACR<30 mg/g,89 cases) and DKD group(UACR≥30 mg/g,33 cases),the clinical data was compared between the two groups.The risk factors of DKD in T2DM patients were analyzed by logistic regression.Receiver operating characteristic(ROC) curve was drawn to evaluate the predictive value of Cys C in the occurrence of DKD.Results Systolic blood pressure,alkaline phosphatase,total protein,globulin,serum creatinine,urinary microalbumin,urinary α_1-microglobulin,UACR,and Cys C in DKD group were higher than those in simple DM group,and the course of disease was longer than that in simple DM group(P<0.05).Logistic regression analysis showed that Cys C was an risk factor for DKD(OR=28.369,95%CI:1.208-666.129,P=0.038).The ROC curve analysis showed that,the area under the curve of Cys C predictive of DKD was 0.757(P<0.05).Conclusion Cys C is closely related to T2DM with DKD,and detection of Cys C can be used to evaluate the progression of DKD.

关 键 词：2型糖尿病 糖尿病肾病 半胱氨酸蛋白酶抑制剂C 尿白蛋白与肌酐比值 

分 类 号：R587.2[医药卫生—内分泌]