坚骨胶囊对气滞血瘀型肘关节骨关节炎的影响  

Effect of Jiangu Capsules on elbow osteoarthritis of stagnation of qi and blood stasis type

作　　者：王伟[1] 李世英[1] 郭晓平 张桐桐 高星 孟玉凤 贾芳莹 WANG Wei;LI Shiying;GUO Xiaoping;ZHANG Tongtong;GAO Xing;MENG Yufeng;JIA Fangying(Department of Hand Surgery,Cangzhou Hospital of Integrated Traditional Chinese Medicine-Western Medicine,Hebei Province,Cangzhou061000,China;Department of Cardiology,Cangzhou Hospital of Integrated Traditional Chinese Medicine-Western Medicine,Hebei Province,Cangzhou061000,China;Department of Function,Cangzhou Hospital of Integrated Traditional Chinese Medicine-Western Medicine,Hebei Province,Cangzhou061000,China;Department of Radiology,Cangzhou Hospital of Integrated Traditional Chinese Medicine-Western Medicine,Hebei Province,Cangzhou061000,China)

机构地区：[1]河北省沧州中西医结合医院手外科,河北沧州061000 [2]河北省沧州中西医结合医院心内科,河北沧州061000 [3]河北省沧州中西医结合医院功能科,河北沧州061000 [4]河北省沧州中西医结合医院放射科,河北沧州061000

出　　处：《中国医药导报》2024年第12期80-83,共4页China Medical Herald

基　　金：河北省中医药管理局中医药类科研计划项目(2021299)。

摘　　要：目的 探讨坚骨胶囊治疗气滞血瘀型肘关节骨关节炎的临床效果。方法 选择2018年1月至2021年6月河北省沧州中西医结合医院收治的气滞血瘀型肘关节骨关节炎患者90例,按照随机数字表法将其分成两组,每组45例。观察组采用坚骨胶囊联合玻璃酸钠治疗,对照组单用玻璃酸钠治疗,两组连续治疗5周。比较两组临床疗效,比较治疗前后Mayo肘关节功能评分(MEPS)、患侧肘关节关节活动度(ROM)、视觉模拟评分法(VAS)评分,以及关节滑液中基质金属蛋白酶-3(MMP-3)、白细胞介素-1β(IL-1β)、软骨寡聚基质蛋白(COMP)、转化生长因子-β_(1)(TGF-β_(1))水平。比较两组不良反应发生情况。结果 观察组临床疗效优于对照组(P<0.05)。治疗后,两组MEPS评分、肘关节ROM高于治疗前,VAS评分低于治疗前,且观察组MEPS评分、肘关节ROM高于对照组,VAS评分低于对照组(P<0.05)。治疗后,两组关节滑液中MMP-3、IL-1β、COMP水平低于治疗前,关节滑液中TGF-β_(1)水平高于治疗前,且观察组关节滑液中MMP-3、IL-1β、COMP水平低于对照组,关节滑液中TGF-β_(1)水平高于对照组(P<0.05)。两组治疗过程中均无明显不良反应发生。结论 联合坚骨胶囊治疗能更有效地调控气滞血瘀型肘关节骨关节炎患者关节滑液中MMP-3、IL-1β、COMP和TGF-β_(1)的表达水平,促进关节软骨修复。Objective To investigate the clinical effect of Jiangu Capsules in treating elbow osteoarthritis of stagnation of qi and blood stasis type.Methods A total of 90 cases of elbow osteoarthritis with stagnation of qi and blood stasis type in Cangzhou Hospital of Integrated Traditional Chinese Medicine-Western Medicine,Hebei Province from January 2018 to June 2021 were selected and they were divided into two groups according to random number table method,with 45 cases in each group.The observation group was treated with Jiangu Capsules combined with Sodium Hyaluronate,while the control group was treated with Sodium Hyaluronate alone.Both groups were treated for five weeks.The clinical efficacy of the two groups was compared.The Mayo elbow performance score(MEPS),affected elbow joint range of motion(ROM),visual analogue scale(VAS),matrix metalloproteinase-3(MMP-3),interleukin-1β(IL-1β),cartilage oligomeric matrix protein(COMP),transforming growth factor-β1(TGF-β1) in synovium before and after treatment were compared.The occurrence of adverse reactions of the two groups were compared.Results The clinical effect of the observation group was better than that of the control group(P<0.05).After treatment,MEPS score and elbow joint ROM in both groups were higher than those before treatment,and VAS score in both groups was lower than that before treatment,and MEPS score and elbow joint ROM in the observation group were higher than the control group,VAS score in the observation group was lower than the control group(P<0.05).After treatment,the levels of MMP-3,IL-1β,and COMP in synovial fluid of the two groups were lower than those before treatment,and the levels of TGF-β1in synovial fluid of the two groups were higher than those before treatment,and the levels of MMP-3,IL-1β,and COMP in synovial fluid of the observation group were lower than those of the control group,and the levels of TGF-β1in synovial fluid of the joint were higher than those of the control group(P<0.05).There were no obvious adverse reactions during

关 键 词：坚骨胶囊 肘关节骨关节炎 气滞血瘀证 血液流变学 滑膜炎症 

分 类 号：R269[医药卫生—中西医结合]