胆汁酸代谢与代谢性疾病关系和作用机制的研究进展  

Research progress on relationship and mechanism of action between bile acid metabolism and metabolic diseases

作　　者：张珂承 吴仪伟 蒋元霜 陈琰[1] ZHANG Kecheng;WU Yiwei;JIANG Yuanshuang;CHEN Yan(Department of Endocrinology,the Second Hospital of Jilin University,Jilin Province,Changchun 130041,China)

机构地区：[1]吉林大学第二医院内分泌科,吉林长春130041

出　　处：《中国医药导报》2024年第13期188-190,共3页China Medical Herald

基　　金：吉林省自然科学基金面上项目(医学科学领域)(YDZJ202301ZYTS074)。

摘　　要：胆汁酸是一种内源性信号分子,通过激活其受体如Takeda G蛋白偶联受体5(TGR5)、法尼醇X受体(FXR)等影响糖脂代谢。胆汁酸代谢与代谢性疾病如肥胖、2型糖尿病、非酒精性脂肪性肝病等双相相关。TGR5不仅可以促进褐色脂肪产热,抑制肝脂肪变性,增强胰岛素敏感性,还可以通过中枢调控抑制食欲。FXR可调控胆汁酸的合成、转运,影响非酒精性脂肪性肝病的发生和发展。本文整理了国内外有关胆汁酸代谢与代谢性疾病的研究进展,提供了一些可能用于代谢性疾病诊断、疗效评估的潜在生物标志物,以期为相关疾病的预防、诊断、治疗提供新的思路。Bile acid is endogenous signal molecule that affects glucose and lipid metabolism by activating its receptor such as Takeda G protein-coupled receptor 5(TGR5) and farnesol X receptor(FXR).Bile acid metabolism is biphasic with metabolic diseases such as obesity,type 2 diabetes,non-alcoholic fatty liver disease,etc.TGR5 can not only promote thermogenesis of brown adipose tissue,inhibit hepatic steatosis,enhance insulin sensitivity,but also suppress appetite through central regulation.FXR can regulate the synthesis and transport of bile acids,affecting the occurrence and development of non-alcoholic fatty liver disease.This article summarizes the research progress on bile acid metabolism and metabolic diseases at home and abroad,and provides some potential biomarkers that may be used for the diagnosis and efficacy evaluation of metabolic diseases,in order to provide new ideas for the prevention,diagnosis and treatment of related diseases.

关 键 词：胆汁酸代谢 糖尿病 肥胖 非酒精性脂肪性肝病 

分 类 号：R589[医药卫生—内分泌]