CML、sRAGE、esRAGE对冠心病动脉粥样硬化的诊断价值  

Diagnostic value of CML,sRAGE and esRAGE in coronary atherosclerosis

作　　者：李玲[1] 郭健[1] 王乐怡 张秀敏 LI Ling;GUO Jian;WANG Leyi;ZHANG Xiumin(Xinjiang Uygur Autonomous Region People's Hospital,Xinjiang Wulumuqi 830001,China)

机构地区：[1]新疆维吾尔自治区人民医院,新疆乌鲁木齐830001

出　　处：《中国实验诊断学》2024年第5期519-522,共4页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨ε-羧甲基赖氨酸(CML)、可溶性晚期糖基化终产物受体(sRAGE)、内源性可溶性晚期糖基化终产物受体(esRAGE)对冠心病动脉粥样硬化的诊断价值。方法2020年6月至2022年12月,于新疆维吾尔自治区人民医院选取冠心病患者100例作为观察组。同时选取100例在我院体检的正常人作为对照组。比较两组ε-羧甲基赖氨酸(CML)、可溶性晚期糖基化终产物受体(sRAGE)和内源性分泌性晚期糖基化终产物受体(esRAGE)水平。应用受试者操作者特征(ROC)曲线评价CML、sRAGE、esRAGE的诊断水平,并联合检测冠心病动脉粥样硬化。结果与对照组相比,观察组血清CML及sRAGE水平明显升高,而esRAGE水平呈下降趋势。血清CML、sRAGE和esRAGE可准确诊断冠心病动脉粥样硬化,联合检测灵敏度(90.91%)、特异性(68.66%)、准确性(76.00%)、阳性预测值(58.82%)、阴性预测值(93.88%)、ROC曲线下面积(AUC)(0.922)较高。结论CML、sRAGE、esRAGE与冠心病动脉粥样硬化有关,有利于临床诊断和治疗。Objective To investigate the diagnostic value of e-carboxymethyl lysine(CML),soluble advanced glyca-tion end product receptor(sRAGE)and endogenous soluble advanced glycation end product receptor(esRAGE)in coro-nary artery disease atherosclerosis.Methods From June 2020 to December 2022,100 patients with coronary heart dis-ease were selected as the observation group in Xinjiang Uygur Autonomous Region Peple's Hospital.At the same time,1oo normal people who were physically examined in our hospital were selected as the control group.The levels of e-car-boxymethyllysine(CML),soluble advanced glycosylation end-product receptor(sRAGE)and endogenous secreted ad-vanced glycosylation end-product receptor(esRAGE)were compared between the two groups.The subject operator characteristics(ROC)curve was used to evaluate CML,sRAGE,Diagnostic level of esRAGE,combined with detection of severe atherosclerosis in coronary heart disease.Results sCompared with the control group,the serum CML and sRAGE levels in the observation group increased significantly,while the esRAGE levels showed a downward trend.Ser-um CML,sRAGE and esRAGE can accurately diagnose severe atherosclerosis in coronary heart disease,and the com-bined detection sensitivity(90.91%),specificity(68.66%),accuracy(76.00%),positive predictive value(58.82%),nega-tive predictive value(93.88%),and area under the ROC curve(AUC)(0.922)are high.Conclusion CML,sRAGE,and es-RAGE are related to atherosclerosis in coronary heart disease,which is conducive to clinical diagnosis and treatment.

关 键 词：ε-羧甲基赖氨酸 可溶性晚期糖基化终产物受体 内源性分泌性晚期糖基化终产物受体 冠状动脉粥样硬化性心脏病 

分 类 号：R541.4[医药卫生—心血管疾病]