脂蛋白(α)与二尖瓣环钙化关系的研究进展  

R541Research progress on the association between lipoprotein(α)and mitral annulus calcifi cation

作　　者：张斌 裴志强 马登峰 邱金 任倩 赵淑珍 ZHANG Bin;PEI Zhi-qiang;MA Deng-feng;QIU Jin;REN Qian;ZHAO Shu-zhen(Department of Cardiology,Taiyuan City Central Hospital,Ninth Clinical Medical College of Shanxi Medical University,Taiyuan 030009,China;Department of Cardiology,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Changzhi Medical College,Changzhi 046099,China)

机构地区：[1]山西医科大学第九临床医学院,太原市中心医院心内科,山西太原030009 [2]复旦大学附属中山医院心内科,上海200032 [3]长治医学院,山西长治046099

出　　处：《中国介入心脏病学杂志》2024年第5期261-265,共5页Chinese Journal of Interventional Cardiology

基　　金：中国医学科学院中央级公益性科研院所基本科研业务费专项资金资助项目(2022-JKCS-30)。

摘　　要：二尖瓣环钙化(MAC)是与年龄相关的局部纤维支持结构的慢性、退行性病变。目前研究认为它是类似动脉粥样硬化和主动脉瓣钙化主动发生的过程,都伴有脂蛋白(α)[Lp(α)]的沉积和慢性炎症灶的形成。其中,Lp(α)是研究的热点。近年来,Lp(α)与主动脉瓣钙化的关系得到了广泛关注,已有大量研究证明,升高的Lp(α)及其相关的氧化磷脂(OxPL)可以通过多种钙调节途径促进主动脉瓣钙化、狭窄,但MAC的病理生理过程是更加复杂和不明确的。目前Lp(α)与MAC的关系有了初步探索。本文将从MAC、Lp(α)以及两者之间的研究进展三方面进行综述,使两者目前的关系更加清晰,从而为预防或延缓MAC提供新的可能。Mitral annular calcification(MAC)is an age-related,chronic,degenerative change in localized fibrous support structures,and current research suggests that it is a process similar to the active onset of atherosclerosis and aortic valve calcification,both of which are accompanied by the deposition of lipoprotein(α)[Lp(α)]and the formation of chronic inflammatory foci.Among them,Lp(α)is the hot spot of research.In recent years,the relationship between Lp(α)and aortic valve calcification has received extensive attention.A large number of studies have demonstrated that elevated Lp(α)and its associated oxidized phospholipids(OxPL)can promote aortic valve calcification and stenosis through multiple calcium-regulated pathways,but the pathophysiological process of MAC is much more complex and unclear,and there has been a preliminary exploration of the relationship between Lp(α)and MAC.To make the current relationship between the two clearer,and thus provide new possibilities for preventing or delaying MAC,the paper will review the three aspects of MAC,Lp(α),and the research progress between the two.

关 键 词：二尖瓣环钙化 脂蛋白(Α) 主动脉瓣钙化 

分 类 号：R541[医药卫生—心血管疾病]