先天性免疫在钙化性主动脉瓣疾病中的作用  

The role of innate immunity in calcific aortic valve disease

作　　者：林湘杰 曾庆春 LIN Xiangjie;ZENG Qingchun(Department of Cardiology,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong 510515,China)

机构地区：[1]南方医科大学南方医院心血管内科,广东省广州市510515

出　　处：《中国动脉硬化杂志》2024年第6期461-465,共5页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金面上项目(81770386、82070403)。

摘　　要：钙化性主动脉瓣疾病(CAVD)是影响心脏瓣膜的最常见疾病,其特征是主动脉瓣瓣小叶的增厚、纤维化和矿化,目前尚无有效的药物治疗。主动脉瓣钙化是一个复杂的、多因素影响的过程,包括瓣膜炎症、纤维化、钙化以及瓣膜增厚和心流出道阻塞。CAVD的确切病理生理机制尚不完全清楚,但许多研究表明先天免疫细胞在主动脉瓣钙化的发展中起关键作用。该综述主要阐述目前关于先天性免疫细胞在CAVD发展中的作用。Calcific aortic valve disease(CAVD)is the most common disease affecting the heart valves,characterized by thickening,fibrosis,and mineralization of the aortic valve leaflets.Currently,there is no effective pharmacological treatment.Aortic valve calcification is a complex and multifactorial process involving valve inflammation,fibrosis,calcification,valve thickening and outflow tract obstruction.The exact pathophysiological mechanisms of CAVD are not fully understood,but many studies have suggested that innate immune cells play a key role in the development of aortic valve calcification.This review focuses on the current role of innate immune cells in the development of CAVD.

关 键 词：先天性免疫 钙化性主动脉瓣疾病 炎症 

分 类 号：R5[医药卫生—内科学]