心肌缺血再灌注损伤中的线粒体相关细胞器串扰  

Mitochondria-associated organelle crosstalk in myocardial ischemia/reperfusion injury

作　　者：姚慧 谢玉鑫 李朝荃 刘婉婷 骆雅倩 易光辉[1,2] YAO Hui;XIE Yuxin;LI Chaoquan;LIU Wanting;LUO Yaqian;YI Guanghui(Institute of Cardiovascular Disease,University of South China&Key Laboratory for Arteriosclerology of Hunan Province&Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease;Department of Pharmacology,School of Pharmacy,University of South China,Hengyang,Hunan 421001,China)

机构地区：[1]南华大学心血管疾病研究所,动脉硬化学湖南省重点实验室,湖南省动脉硬化性疾病国际科技创新合作基地 [2]南华大学药学院药理学教研室,湖南省衡阳市421001

出　　处：《中国动脉硬化杂志》2024年第6期481-486,共6页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(81770490);湖南省自然科学基金项目(2020JJ4535)。

摘　　要：细胞器损伤是导致心肌缺血再灌注损伤的重要因素。这种损伤会导致线粒体及相关细胞器的功能改变。线粒体与其他细胞器的串扰同样影响心脏缺血再灌注损伤的发生发展,例如线粒体相关内质网膜使得线粒体和内质网“无缝连接”,调节线粒体和内质网之间的细胞器和代谢物(包括离子、脂质和蛋白质)交换,从而影响心肌缺血再灌注损伤。然而,线粒体与相关细胞器串扰是触发心肌缺血再灌注损伤的关键因素,目前相关报道有限。因此,该文阐述了线粒体与内质网、溶酶体和细胞核串扰在心肌缺血再灌注损伤中的作用,旨在为靶向线粒体与其他细胞器的串扰治疗心肌缺血再灌注损伤的研究提供一定的理论依据。Damage to organelles plays a significant role in myocardial ischemia/reperfusion injury,which results in the dysfunction of mitochondria and other related organelles.The communication between mitochondria and other organelles can also affect the development of myocardial ischemia/reperfusion injury.For instance,the mitochondria-associated endoplasmic reticulum membrane provides a“seamless connection”and regulates the exchange of organelles and metabolites(such as ions,lipids and proteins)between the mitochondria and the endoplasmic reticulum,which subsequently affects myocardial ischemia/reperfusion injury.However,there is a lack of studies regarding the interaction between mitochondria and related organelles,which is a critical component in triggering myocardial ischemia/reperfusion injury.Therefore,this article describes the role of mitochondrial crosstalk with endoplasmic reticulum,lysosomes and nuclei in myocardial ischemia/reperfusion injury,and aims to provide a theoretical basis for targeting mitochondrial crosstalk with other organelles in the treatment of myocardial ischemia/reperfusion injury.

关 键 词：线粒体 细胞器串扰 心肌缺血再灌注损伤 线粒体相关内质网膜 溶酶体 细胞核 

分 类 号：R5[医药卫生—内科学] R363[医药卫生—临床医学]