二肽基肽酶4及其生理底物在心肌缺血再灌注损伤中的作用  

The role of dipeptidyl peptidase 4 and its physiological substrate in myocardial ischemia/reperfusion injury

作　　者：王玲伟 雷江辉 朱雅迪 杨思远 钱星凯 WANG Lingwei;LEI Jianghui;ZHU Yadi;YANG Siyuan;QIAN Xingkai(Translational Medicine Research Center,Guizhou Medical University,Guiyang,Guizhou 550025,China;Department of Cardiac Surgery,the Affiliated Hospital of Guizhou Medical University,Guiyang,Guizhou 550001,China;Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases,Guizhou Medical University;School of Pharmaceutical Sciences,Guizhou Medical University,Guiyang,Guizhou 550025,China)

机构地区：[1]贵州医科大学转化医学研究中心,贵州省贵阳市550025 [2]贵州医科大学附属医院心脏外科,贵州省贵阳市550001 [3]贵州医科大学常见慢性疾病发病机制及药物研究重点实验室 [4]贵州医科大学药学院,贵州省贵阳市550025

出　　处：《中国动脉硬化杂志》2024年第6期532-538,共7页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(82304611);贵州省基础研究计划项目(黔科合基础-ZK[2022]一般376);基础药理教育部重点实验室(遵义医科大学)开放课题(黔教合KY字[2022]393号);贵州省卫生健康委科学技术基金项目(gzwkj2022-088)。

摘　　要：心肌缺血再灌注损伤(MIRI)发生在体外循环心内直视手术、心血管介入和溶栓等治疗后,是导致治疗后患者心功能不全、心力衰竭甚至死亡的最主要原因。近年来研究发现,内源性活性肽的释放可以缓解MIRI的产生,通过调节内源性肽的功能和作用可能是治疗MIRI最有效的途径之一。二肽基肽酶4(DPP4)是哺乳动物体内重要的丝氨酸蛋白酶,具有水解内源性肽的酶活性,其在体内的功能作用主要是代谢体内的短肽,包括生长因子、激素等。该综述通过阐述DPP4对内源性肽的水解作用在MIRI中的影响,旨在更好地认识并寻找有效的治疗靶点,最终为MIRI的治疗作用提供新的思路。Myocardial ischemia/reperfusion injury(MIRI)occurs after cardiopulmonary bypass open heart surgery,cardiovascular intervention and thrombolytic therapy,which is the most important cause of cardiac insufficiency,heart failure,and even death in patients after treatment.In recent years,studies have found that the release of endogenous active peptides can alleviate the production of MIRI,and regulating the function and action of endogenous peptides may be one of the most effective ways to treat MIRI.Dipeptidyl peptidase 4(DPP4)is an important serine protease in mammals,with enzymatic activity to hydrolyze endogenous peptides.Its primary physiological function is to metabolize short peptides,including growth factors,hormones,etc.This review aims to better understand and search for effective therapeutic targets by elucidating the impact of DPP4 on the hydrolysis of endogenous peptides in MIRI,and ultimately provide new ideas for the therapeutic effects of MIRI.

关 键 词：心肌缺再灌注损伤 二肽基肽酶4 内源性肽 

分 类 号：R5[医药卫生—内科学] R363[医药卫生—临床医学]