间充质干细胞在脊髓损伤中的应用及研究进展  

Application and research progress of mesenchymal stem cells in spinal cord injury

作　　者：景水力 王娟[1,2] 刘晔 周亨[1,2] 熊威 叶青松 Jing Shui;Wang Juan;Liu Ye;Zhou Heng;Xiong Wei;Ye Qingsong(Center of Regenerative Medicine,Renmin Hospital of Wuhan University,Wuhan 430060,China;Department of Stomatology,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]湖北武汉大学人民医院再生医学中心,武汉430060 [2]湖北武汉大学人民医院口腔科,武汉430060

出　　处：《中华细胞与干细胞杂志（电子版）》2024年第2期113-121,共9页Chinese Journal of Cell and Stem Cell（Electronic Edition）

基　　金：国家自然科学基金(81871503);湖北省重点研发项目(2022BCA029)。

摘　　要：脊髓损伤(SCI)是一种伴有损伤平面以下感觉和运动障碍的中枢神经系统疾病,严重影响患者的自理能力和生活质量。目前SCI的治疗方法不能满足神经再生和功能恢复的需求。间充质干细胞(MSCs)不仅具有多向分化能力,还通过旁分泌效应发挥神经营养、免疫调节和血管生成活性。MSCs及其衍生物成为极具吸引力的SCI生物疗法,新型生物材料的发展进一步推动相关治疗策略的开发。本文就MSCs在SCI领域的治疗作用及应用进展进行综述,以期为未来的研究提供见解和参考。Spinal cord injury(SCI)is a kind of central nervous system disorder with sensory and motor impairments below the injury level,severely affecting the self-care ability and life quality of patients.The current treatment for SCI fails to meet neural regeneration and functional recovery demands.Mesenchymal stem cells(MSCs)can differentiate multi-directionally and exert neurotrophic,immunomodulatory,and angiogenic activities through paracrine effects.MSCs and their derivatives have become attractive biological therapies for spinal cord injury,and the development of novel biomaterials has further promoted the development of related therapeutic strategies.This review summarizes the therapeutic effect and application progress of MSCs in SCI,aiming to provide insights and references for future research.

关 键 词：脊髓损伤 间充质干细胞 神经分化 旁分泌效应 生物材料 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]