成纤维细胞异质性在炎症免疫性皮肤病中的作用  

Impact of Fibroblast Heterogeneity in Inflammatory Immune Dermatoses

作　　者：王云霞 林福全 许爱娥[2] WANG Yunxia;LIN Fuquan;XU Ai′e(Department of Dermatology,the First Affiliated Hospital of Anhui Medical University,Hefei 230032,China;Department of Dermatology,Hangzhou Third People′s Hospital,Hangzhou 310009,China;Department of Dermatology,Hangzhou Clinical College of Anhui Medical University,Hangzhou 310009,China)

机构地区：[1]安徽医科大学第一附属医院皮肤科,安徽合肥230032 [2]杭州市第三人民医院皮肤科,浙江杭州310009 [3]安徽医科大学杭州临床学院皮肤科,浙江杭州310009

出　　处：《中国皮肤性病学杂志》2024年第6期597-601,共5页The Chinese Journal of Dermatovenereology

基　　金：国家自然科学基金联合基金项目(U22A20310);国家自然科学基金项目(82003322);浙江省自然科学基金项目(LY21H110002);杭州市医学重点学科建设项目(杭卫发〔2021〕21-3)。

摘　　要：成纤维细胞是皮肤真皮中的主要常驻细胞之一,组织状态、区域特征、微环境和细胞状态共同决定了成纤维细胞功能表型的异质性。不同的成纤维细胞亚群通过分泌细胞外基质,以维持组织结构完整性和调节局部微环境,通过分泌细胞因子/趋化因子调节免疫细胞,以参与炎症免疫性皮肤病的激活、代谢等病理生理过程。该文就成纤维细胞异质性在几种炎症免疫性皮肤病发病机制中潜在的作用进行阐述,以期为靶向精准治疗提供新思路。Fibroblasts are one of the main resident cells in the dermis,and fibroblasts have heterogeneity of functional phenotypes.The heterogeneity of fibroblasts is determined by the tissue state,regional characteristics,microenvironment,and cellular status.Different subgroups of fibroblasts secrete extracellular matrix to maintain tissue structural integrity and regulate the local microenvironment.Fibroblasts can regulate immune cells by secreting cytokines/chemokines to participate in pathophysiological processes,such as activation and metabolism of inflammatory immune skin diseases.This article reviews the potential role of fibroblast heterogeneity in the pathogenesis of several inflammatory immune skin diseases,in order to provide new ideas for targeted precision therapy.

关 键 词：成纤维细胞 异质性 炎症性皮肤病 

分 类 号：R751[医药卫生—皮肤病学与性病学]