多杀霉素/羧甲基壳聚糖缓释悬浮剂的制备  

Preparation of spinosad/carboxymethyl chitosan sustained-release suspension concentrate

作　　者：王祎萌 李维坤 张宏光 孙健[2] 孔祥平[2] 张清明 王娟[2] WANG Yimeng;LI Weikun;ZHANG Hongguang;SUN Jian;KONG Xiangping;ZHANG Qingming;WANG Juan(College of Plant Health and Medicine,Qingdao Agricultural University,Qingdao 266109,China;College of Chemistry and Pharmacy,Qingdao Agricultural University,Qingdao 266109,China)

机构地区：[1]青岛农业大学植物医学学院,山东青岛266109 [2]青岛农业大学化学与药学院,山东青岛266109

出　　处：《现代农药》2024年第3期45-50,共6页MODERN AGROCHEMICALS

基　　金：山东省自然科学基金(ZR2021MC072、ZR2022MC213);青岛农业大学实验技术课题(SYJS202322);青岛农业大学研究生创新计划项目(QNYCX24035);青岛农业大学大学生创新训练项目(QNDC20240228)。

摘　　要：基于羧甲基壳聚糖在等电点附近溶解度低的特性,采用pH调节法制备多杀霉素/羧甲基壳聚糖缓释悬浮剂,并初步探究其对小菜蛾幼虫的防治效果。结果表明:缓释悬浮剂适宜的制备条件为羧甲基壳聚糖盐酸溶液质量分数1.0%,多杀霉素甲醇溶液质量分数1.5%,羧甲基壳聚糖与多杀霉素的质量比2∶1,15000 r/min下剪切乳化3 min。缓释悬浮剂呈乳白色,载药量、包封率和中位粒径分别约为25%、74%和48μm,稀释施用时粒径降为约3μm。红外光谱分析表明,羧甲基壳聚糖成功包封多杀霉素,其相互间作用力主要为物理吸附。相对传统悬浮剂,多杀霉素/羧甲基壳聚缓释悬浮剂在防治小菜蛾方面具有优异的速效性和更长的持效期,在多杀霉素减施增效方面具有一定的应用潜力。Based on the low solubility of carboxymethyl chitosan near its isoelectric point,spinosad/carboxymethyl chitosan sustained-release suspension concentrate was prepared by adjusting the pH of the solution.Its control effect on Plutella xylostella(Lepidoptera:Plutellidae)larvae was preliminarily explored.The results showed that the sustained-release suspension concentrate could be prepared under the conditions of carboxymethyl chitosan hydrochloric acid solution 1.0% and spinosad methanol solution 1.5%,the mass ratio of 2∶1(carboxymethyl chitosan to spinosad),at shear emulsification of 15000 r/min for 3 min.The resulted milky white suspension featured a good loading content of 25% and a high encapsulation efficiency of 74%.The median particle size was determined to be about 48μm,which would decrease to approximately 3μm when diluted.Infrared spectrum analysis indicated that the spinosad was successfully encapsulated by carboxymethyl chitosan,and the primary interaction between them was physical adsorption.Comparing with conventional suspension concentrate,the prepared sustained-release formulation had better quick-acting performance and longer duration in controlling Plutella xylostella,which exhibited good application potential in reducing the amount and increasing the efficacy of spinosad.

关 键 词：多杀霉素 羧甲基壳聚糖 pH调节法 缓释悬浮剂 制备 

分 类 号：TQ450.68[化学工程—农药化工]