早发性卵巢功能不全骨骼健康管理研究进展  

Advances in skeletal health management of premature ovarian insufficiency

作　　者：全鑫 娄诤 黄艺舟 周坚红[2] QUAN Xin;LOU Zheng;HUANG Yizhou;ZHOU Jianhong(Department of Gynecology,The Fourth Affiliated Hospital of Zhejiang University School of Medicine,Jinhua,Zhejiang 322000,China;Department of Gynecology,The Affiliated Obstetrics and Gynecology Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang 310000,China)

机构地区：[1]浙江大学医学院附属第四医院妇科,浙江金华322000 [2]浙江大学医学院附属妇产科医院妇科,浙江杭州310000

出　　处：《医药前沿》2024年第16期67-69,共3页Journal of Frontiers of Medicine

基　　金：浙江大学医学院附属妇产科医院“4+X”临床研究启动项目(ZDFY2022-4XA101)。

摘　　要：早发性卵巢功能不全(POI)患者以高促性腺激素和低雌激素为主要特征,通过多种途径影响骨代谢。激素补充可对POI女性发生骨质疏松起到预防的作用。只要没有禁忌证,POI患者应给予激素补充治疗,并应持续治疗至平均自然绝经年龄,之后可参考绝经后HRT方案进行管理。及时、准确诊断和管理POI女性存在的骨骼健康问题,对于降低骨质疏松性骨折及其并发症,提高POI患者的生活质量具有重要意义。Patients with premature ovarian insufficiency(POI)are characterized by hypergonadotropic and hypoestrogenic hormones,which affect bone metabolism through multiple pathways.Hormone supplementation therapy plays a preventive role in the development of osteoporosis in women with POI.As long as there are no contraindications,hormone supplementation therapy should be given to patients with POI and should be continued until the average age of natural menopause,after which it can be managed with reference to a postmenopausal HRT regimen.Timely and accurate diagnosis and management of bone health problems in women with POI is important to reduce osteoporotic fractures and their complications and to improve the quality of life of patients with POI.

关 键 词：综述 早发性卵巢功能不全 骨质疏松症 激素补充治疗 

分 类 号：R711.75[医药卫生—妇产科学]