清肝益阴明目方治疗轻、中度脂质异常型干眼的疗效观察  

Clinical Efficacy Observation of Qinggan Yiyin Mingmu Formula in Treating Mild to Moderate Lipid Abnormality Type Dry Eye Syndrome

作　　者：关爱红 韩冰倩 张南[1] 许家骏[1] 王晓聃 孟悦 冯月 GUAN Aihong;HAN Bingqian;ZHANG Nan;XU Jiajun;WANG Xiaodan;MENG Yue;FENG Yue(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]北京中医药大学东直门医院,北京100700

出　　处：《中国中医眼科杂志》2024年第6期520-524,共5页China Journal of Chinese Ophthalmology

摘　　要：目的观察清肝益阴明目方治疗轻、中度脂质异常型干眼的临床疗效。方法纳入2023年5月—2023年9月北京中医药大学东直门医院诊治的轻、中度脂质异常型干眼患者55例(110只眼),证属肝肾阴虚证,随机分为试验组28例(56只眼)和对照组27例(54只眼)。对照组予0.1%玻璃酸钠滴眼液+睑板腺按摩治疗;试验组在对照组的基础上联合清肝益阴明目方熏蒸+代茶饮治疗。分别在治疗前、后检查受试者的泪膜破裂时间(BUT)、泪河高度、眼表疾病指数(OSDI)评分和中医证候积分。结果2组治疗前BUT、泪河高度、OSDI评分、中医证候积分比较,差异均无统计学意义(P>0.05)。(1)BUT:2组治疗后BUT均较治疗前延长,差异均有统计学意义(t试验组=6.939,P=0.000;t对照组=3.363,P=0.001)。治疗后2组间BUT比较,试验组长于对照组,差异有统计学意义(t=2.251,P=0.026)。(2)泪河高度:试验组治疗后泪河高度较治疗前升高,差异有统计学意义(t=3.680,P=0.000),而对照组治疗后泪河高度与治疗前比较,差异无统计学意义(P>0.05)。治疗后2组间泪河高度比较,试验组高于对照组,差异有统计学意义(t=2.090,P=0.039)。(3)OSDI评分:2组治疗后OSDI评分均较治疗前降低,差异均有统计学意义(t试验组=17.365、t对照组=12.514,均P=0.000)。治疗后2组间OSDI评分比较,试验组低于对照组,差异有统计学意义(t=6.777,P=0.000)。(4)中医证候积分:2组治疗后中医证候积分均较治疗前降低,差异均有统计学意义(t试验组=9.770、t对照组=7.174,均P=0.000)。治疗后2组间中医证候积分比较,试验组低于对照组,差异有统计学意义(t=4.769,P=0.000)。(5)临床疗效:试验组总有效率(92.86%)高于对照组(74.07%),差异有统计学意义(χ2=18.532,P=0.000)。结论清肝益阴明目方有助于提高患者泪膜稳定性,增加泪河高度,改善患者不适症状。OBJECTIVE To observe the clinical efficacy of Qinggan Yiyin Mingmu Formula in treating mild to moderate lipid abnormality type dry eye syndrome.METHODS From May 2023 to September 2023,55 patients(110 eyes)with mild to moderate lipid abnormality type dry eye syndrome diagnosed and treated at Dongzhimen Hospital,Beijing University of Chinese Medicine were included.These patients were classified as having liver-kidney Yin deficiency syndrome and randomly divided into an experimental group(28 cases,56 eyes,EG)and a control group(27 cases,54 eyes,CG).The control group received treatment with 0.1%sodium hyaluronate eye drops combined with eyelid gland massage,while the experimental group received additional treatment with Qinggan Yiyin Mingmu Formula fumigation and herbal tea.The subjects'tear film break-up time(BUT),tear river height,ocular surface disease index(OSDI)scores,and Traditional Chinese Medicine(TCM)syndrome scores were evaluated before and after treatment.RESULTS There were no significant differences in BUT,tear river height,OSDI scores and TCM syndrome scores between the two groups before treatment(P>0.05).(1)BUT:After treatment,BUT was significantly prolonged in both groups compared to before treatment(tEG=6.939,P=0.000;tCG=3.363,P=0.001).The experimental group had a longer BUT than the control group after treatment(t=2.251,P=0.026).(2)Tear river height:Tear river height increased significantly after treatment in the experimental group(t=3.680,P=0.000),while there was no significant difference in the control group(P>0.05).The experimental group had a higher tear river height than the control group after treatment(t=2.090,P=0.039).(3)OSDI scores:After treatment,OSDI scores decreased significantly in both groups compared to before treatment(tEG=17.365,tCG=12.514,both P=0.000),The experimental group had lower OSDI scores than those in the control group after treatment(t=6.777,P=0.000).(4)TCM syndrome scores:After treatment,the TCM syndrome scores decreased significantly in both groups compared to before tre

关 键 词：熏蒸 代茶饮 脂质异常型干眼 清肝益阴明目方 

分 类 号：R276.7[医药卫生—中医五官科学]