糖尿病足溃疡难愈性创面的相关研究进展  

Research progress in refractory wounds of diabetes foot ulcers

作　　者：郭瑞 彭会珍 浦仕彪 赵云丽 GUO Rui;PENG Hui-zhen;PU Shi-biao;ZHAO Yun-li(College of Chinese Material Medicine,Yunnan University of Chinese Medicine,Kunming 650500,China;Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education and Yunnan Province,Yunnan Characteristic Plant Extraction Laboratory,Yunnan Provincial Center for Research&Development of Natural Products,School of Pharmacy,Yunnan University,Kunming 650500,China)

机构地区：[1]云南中医药大学中药学院,云南昆明650500 [2]云南大学自然资源药物化学教育部重点实验室,云南省特色植物提取实验室,云南省天然产物转化与应用重点实验室,药学院,云南昆明650500

出　　处：《云南民族大学学报（自然科学版）》2024年第3期325-334,376,共11页Journal of Yunnan Minzu University:Natural Sciences Edition

基　　金：云南省重大科技专项(202202AA100004、202302AA310013);云南省应用基础研究面上项目(202201AT070079);云南省中青年学术和技术带头人后备人才(202305AC16007).

摘　　要：糖尿病患者的下肢并发症已成为全球日益重视的公共卫生问题,作为其中最为严重的并发症,糖尿病足溃疡的发病率、截肢率及病死率显著,且治疗成本高昂.现阶段由于高糖环境的影响该病病情较为复杂,发病机制尚未完全探明,缺乏精准治疗策略,还无法彻底攻克这一痼疾.糖尿病足溃疡需要确定病因机制并评估合并症,以提供正确的治疗方法,这是降低下肢截肢风险的关键.综述了糖尿病足溃疡的高威胁因素、发病机制及当前治疗策略的相关研究,为糖尿病患者慢性难愈性皮肤损伤的预防及选择最佳的临床治疗方法提供参考.Lower limb complications of patients with diabetes have become an increasingly important public health problem in the world.As one of the most serious complications,diabetic foot ulcerationshave significant morbidity,amputation and mortality rates and are costly to treat.At present,due to the influence of the high sugar environ⁃ment,the disease is relatively complex,the pathogenesis has not been fully explored,and the lack of precise treat⁃ment strategies cannot completely overcome this chronic disease.The etiology mechanism and complications of dia⁃betes foot ulcer needs to be determined and evaluated to provide correct treatment,which is a key to reduce the risk of lower limb amputation.The high threat factors,pathogenesis and current treatment strategies of diabetes foot ulcer were reviewed in this article.

关 键 词：糖尿病足溃疡 高威胁因素 发病机制 治疗手段 

分 类 号：R969[医药卫生—药理学]