上消化道肿瘤光动力治疗中光敏剂的应用综述  

Application of photosensitizers in photodynamic therapy for upper gastrointestinal tumors

作　　者：李佳航 李永亮[1] 冯海龙 张馨元 王宁 上官佳伟 LI Jiahang;LI Yongliang;FENG Hailong;ZHANG Xinyuan;WANG Ning;SHANGGUAN Jiawei(School of Optoelectronic Engineering,Changchun University of Science and Technology,Changchun 130022,China)

机构地区：[1]长春理工大学光电工程学院,长春130012

出　　处：《激光杂志》2024年第5期15-19,共5页Laser Journal

基　　金：国家自然科学基金面上项目(No.62075018)。

摘　　要：国家癌症中心统计数据显示,2022年我国上消化道肿瘤死亡病例近50万,严重威胁人民群众的健康安全。光动力治疗上消化道肿瘤是通过内镜及传导光纤将治疗激光束引入体内对病灶进行靶向治疗,已成为近年来临床治疗肿瘤的效果最佳、副作用最少的医学方式。影响光动力治疗效果的关键因素之一是光敏剂的类型和剂量。通过研究光敏剂发展情况、在上消化道肿瘤治疗中的应用现状以及治疗效果等,对比国内外研究进展,分析了光动力治疗中对光敏剂的特性要求以及未来的研究方向。According to the statistics of the National Cancer Center,there were nearly half a million deaths from upper gastrointestinal tumors in China in 2022,which seriously threatens the health and safety of the people.Photodynamic therapy for upper gastrointestinal tumors is the targeted treatment of lesions by introducing the therapeutic laser beam into the body through endoscopy and conduction fiber,which has become a medical method with the best effect and the least side effects in clinical treatment of tumors in recent years.One of the key factors affecting the efficacy of photodynamic therapy is the type and dose of photosensitizer.This paper studies the development of photosensitizers,their current application status and therapeutic effects in the treatment of upper gastrointestinal tumors.It compares the research progress at home and abroad,analyzes the characteristics and requirements of photosensitizers in photodynamic therapy,and discusses the future research directions.

关 键 词：光动力治疗 光敏剂 上消化道 肿瘤 

分 类 号：TN212[电子电信—物理电子学]