益气通络排浊颗粒对慢性非细菌性前列腺炎大鼠IL-8、IL-10的影响  

Effect of Yiqi Tongluo Paizhuo Granules(益气通络排浊颗粒)on IL-8 and L-10 in Rats with Chronic Non-Bacterial Prostatitis

作　　者：田杨 王那钦 王家辉 TIAN Yang;WANG Naqin;WANG Jiahui(The Second Clinical College of Liaoning University of Traditional Chinese Medicine,Shenyang 110034,Liaoning,China;Hainan Hospital of Traditional Chinese Medicine,Haikou 570000,Hainan,China;Hainan Provincial Peoples Hospital,Haikou 570000,Hainan,China)

机构地区：[1]辽宁中医药大学第二临床学院,辽宁沈阳110034 [2]海南省中医院,海南海口570000 [3]海南省人民医院,海南海口570000

出　　处：《实用中医内科杂志》2024年第6期119-123,I0022,I0023,共7页Journal of Practical Traditional Chinese Internal Medicine

基　　金：海南省自然科学基金项目(818MS062);海南省重点研发计划项目(ZDYF2018125)。

摘　　要：目的 通过检测角叉菜胶诱导的慢性非细菌性前列腺炎(CNP)大鼠前列腺组织中白介素-8(IL-8)和白介素-10(IL-10)水平,进而探讨益气通络排浊颗粒对慢性非细菌性前列腺炎(CNP)的作用机制。方法 将56只SPF级Wistar大鼠随机分为空白组、模型组、中药对照组、西药对照组、益气通络排浊颗粒高剂量组、中剂量组、低剂量组。采用HE染色观察前列腺组织结构;ELISA法和PCR法测定各组前列腺组织白介素-8(IL-8)和白介素-10(IL-10)水平。结果 前列腺HE染色切片显示前列腺治疗前空白组与治疗前模型组对比间质可见个别小灶性血管充血、水肿、少许炎细胞浸润。各治疗组前列腺腺体腺腔内未见炎细胞、腺体上皮炎细胞浸润及间质充血、水肿、炎细胞浸润有不同程度减轻。与空白组相比,模型组大鼠前列腺组织IL-8水平增加(P<0.05),IL-10水平降低(P<0.05);与模型组相比,给药组大鼠前列腺组织IL-8水平降低(P<0.05),IL-10水平增加(P<0.05)。结论 益气通络排浊颗粒能降低角叉菜胶诱导的慢性非细菌性前列腺炎大鼠前列腺组织IL-8水平,升高IL-10水平,可能通过调节IL-8和IL-10的水平缓解炎症。The prevalence of chronic kidney disease is increasing year by year.Immune-mediated glomerulonephritis is the most common glomerular disease in China,and it is also the main cause of the end-stage renal disease.The development and progress of modern medicine provides doctors with a microscopic perspective to understand diseases,namely in the process of col-lecting syndrome differentiation material in clinic,relying on the advanced technology of modern medicine,from the micro per-spective of the characteristics of the body structure,metabolism and function,more accurate and detailed understanding of the ma-terial basis of the traditional Chinese medicine syndrome and the traditional macro syndrome complement,laboratory pathology and inspection results,as the"image"of the human body,can be regarded as the extension of the four diagnosis methods of traditional Chinese medicine,is also the important basis of traditional Chinese medicine microscopic syndrome differentiation for kidney dis-ease.This paper summarized the development of immune-mediated glomerulonephritis in TCM.

关 键 词：益气通络排浊颗粒 慢性非细菌性前列腺炎 作用机制 

分 类 号：R697.3[医药卫生—泌尿科学]