碳纳米管的血管内皮细胞损伤作用研究进展  

Research progress on the damage of carbon nanotubes to vascular endothelial cells

作　　者：赵小梅(综述) 姜淼(审校) ZHAO Xiaomei;JIANG Miao(School of Public Health,University of South China,Hengyang,Hunan 421000,China;Institute of Cardiovascular Diseases,Hengyang Medical College,University of South China/Department of Bioinformatics and Medical Big Data/Key Laboratory for Arteriosclerology of Hunan Province/Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease,Hengyang,Hunan 421000,China)

机构地区：[1]南华大学公共卫生学院,湖南衡阳421000 [2]南华大学衡阳医学院心血管疾病研究所/生物信息与医学大数据教研室/动脉硬化学湖南省重点实验室/湖南省动脉硬化性疾病国际科技创新合作基地,湖南衡阳421000

出　　处：《现代医药卫生》2024年第11期1917-1921,共5页Journal of Modern Medicine & Health

基　　金：国家自然科学基金青年项目(32101018);湖南省自然科学基金面上项目(2023JJ30522)。

摘　　要：碳纳米管作为新型纳米材料,广泛应用于生物医学领域。通过呼吸道、消化道及循环直接接触,碳纳米管均可以接触血管内皮细胞,产生内皮损伤作用。该文综述了影响碳纳米管对内皮细胞损伤作用的因素,梳理了碳纳米管对内皮细胞炎症反应、单核细胞黏附能力、脂质蓄积能力、内皮通透性、血管形成能力、促凝能力等方面的影响。同时,该文总结了动物实验中碳纳米管通过损伤内皮细胞促进动脉粥样硬化斑块形成及血-脑屏障功能损伤,以期为碳纳米管在生物医学领域中的应用提供决策参考。Carbon nanotubes as novel nanomaterials,which are widely used in biomedical field.Through the respiratory tract,digestive tract,and circulation,carbon nanotubes can come into contact with vascular endothelial cells and damage the endothelial cells.In this paper,the factors effecting the damage of carbon nanotubes to endothelial cells was reviewed,and the effects of carbon nanotubes on endothelial cell inflammation,monocyte adhesion,lipid accumulation,endothelial permeability,angiogenesis,and pro-coagulant ability were reviewed.Meanwhile,this paper reviewed that carbon nanotubes promote the formation of atherosclerotic plaques and the impairment of blood-brain barrier function by damaging endothelial cells in animal experiments,so as to provide a reference for decision-making on the application of carbon nanotubes in biomedical field.

关 键 词：碳纳米管 内皮细胞 动脉粥样硬化 血-脑屏障 综述 

分 类 号：R714.252[医药卫生—妇产科学]