肛裂切除加肛门内括约肌切开术治疗肛裂患者的临床效果研究  

Study on clinical effect of anal fissure resection combined with internal anal sphincterotomy in the treatment of anal fissure patients

作　　者：卓芹超 ZHUO Qin-chao(Jinxiang County People's Hospital,Jining 272200,China)

机构地区：[1]金乡县人民医院,272200

出　　处：《中国实用医药》2024年第10期39-42,共4页China Practical Medicine

摘　　要：目的 在肛裂患者手术治疗中,采用肛裂切除加肛门内括约肌切开术治疗,分析其临床效果。方法 选取45例肛裂手术治疗患者作为研究对象,所有患者均展开肛裂切除加肛门内括约肌切开术。比较患者手术前后的临床相关指标(疼痛评分、肿胀评分)、炎性因子[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、 γ干扰素(IFN-γ)]水平、生活质量评分。结果 患者手术后疼痛评分(3.32±1.13)分、肿胀评分(1.23±0.21)分均低于手术前的(5.48±1.14)、(2.87±0.23)分,差异具有统计学意义(P<0.05)。患者手术后的hs-CRP(9.62±1.53)mg/L、TNF-α(30.23±3.57)pg/ml、IL-6(66.35±5.08)ng/L、IL-8(32.74±3.17)ng/L、IFN-γ(54.78±2.01)pg/ml均低于手术前的(16.25±2.04)mg/L、(40.15±4.09)pg/ml、(83.37±8.38)ng/L、(45.58±3.45)ng/L、(63.43±3.15)pg/ml,差异具有统计学意义(P<0.05)。患者手术后的躯体功能、心理功能、社会功能、物质生活评分分别为(78.84±2.78)、(77.27±2.23)、(78.83±2.77)、(77.32±2.26)分,均高于手术前的(72.13±2.07)、(71.19±2.28)、(73.19±2.56)、(72.47±2.59)分,差异具有统计学意义(P<0.05)。结论 在肛裂患者手术治疗中,采用肛裂切除加肛门内括约肌切开术治疗,能减轻术后疼痛及患处肿胀,减轻体内炎性反应,提高患者生活质量,值得临床推广。Objective To analyze the clinical effect of anal fissure resection combined with internal anal sphincterotomy in the treatment of anal fissure patients.Methods 45 patients who underwent anal fissure surgery were selected as the research subjects.All patients underwent anal fissure resection and internal anal sphincterotomy.Comparison was made on clinical indicators(pain score and swelling score),inflammatory markers[hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8),interferon-γ(IFN-γ)],and quality of life before and after surgery between the two groups.Results After surgery,the postoperative pain score was(3.32±1.13)points and swelling score was(1.23±0.21)points,which were lower than(5.48±1.14)and(2.87±0.23)points before surgery(P<0.05).After surgery,patients had hs-CRP of(9.62±1.53)mg/L,TNF-αof(30.23±3.57)pg/ml,IL-6 of(66.35±5.08)ng/L,IL-8 of(32.74±3.17)ng/L,IFN-γof(54.78±2.01)pg/ml,which were lower than(16.25±2.04)mg/L,(40.15±4.09)pg/ml,(83.37±8.38)ng/L,(45.58±3.45)ng/L,(63.43±3.15)pg/ml before surgery.The difference was statistically significant(P<0.05).After surgery,the scores of physical function,psychological function,social function and material life were(78.84±2.78),(77.27±2.23),(78.83±2.77)and(77.32±2.26)points,which were higher than(72.13±2.07),(71.19±2.28),(73.19±2.56)and(72.47±2.59)points before surgery,and the difference was statistically significant(P<0.05).Conclusion In the surgical treatment of anal fissure patients,the use of anal fissure resection combined with internal anal sphincterotomy can reduce postoperative pain and swelling,alleviate inflammatory reactions in the body,and improve patient quality of life,which is worthy of clinical promotion.

关 键 词：肛裂切除术 肛门内括约肌切开术 临床效果观察 

分 类 号：R657.14[医药卫生—外科学]