西替利嗪联合加味犀角地黄汤治疗小儿过敏性紫癜血热夹瘀证的临床效果观察  

Observation on clinical effect of cetirizine combined with modified Xijiao Dihuang Decoction in the treatment of children with henoch schonlein purpura(blood heat and blood stasis syndrome)

作　　者：张丽茹 ZHANG Li-ru(Yuncheng County Hospital of Traditional Chinese Medicine,Heze 274700,China)

机构地区：[1]郓城县中医医院,274700

出　　处：《中国实用医药》2024年第10期43-47,共5页China Practical Medicine

摘　　要：目的 探讨西替利嗪联合加味犀角地黄汤治疗小儿过敏性紫癜血热夹瘀证的临床效果。方法 选取60例小儿过敏性紫癜血热夹瘀证患儿作为研究对象,随机分为对照组和观察组,每组30例。对照组给予西替利嗪治疗,观察组在对照组的基础上给予加味犀角地黄汤治疗。对比两组患儿的临床疗效、症状缓解时间、复发率及不良反应发生情况。结果 观察组的临床总有效率96.67%明显高于对照组的73.33%,差异具有统计学意义(P<0.05)。观察组的皮肤症状、关节症状、胃肠道症状缓解时间分别为(6.61±1.11)、(3.18±0.68)、(11.46±2.25)d,均短于对照组的(11.71±1.57)、(7.77±1.39)、(20.21±4.27)d,差异具有统计学意义(P<0.05)。观察组的复发率6.67%明显低于对照组的30.00%,差异具有统计学意义(P<0.05)。观察组的不良反应发生率略低于对照组,但差异未达到统计学显著性(P>0.05)。结论 西替利嗪联合加味犀角地黄汤治疗小儿过敏性紫癜血热夹瘀证的临床效果显著,可缩短症状缓解时间,降低复发率,且不良反应较少,值得临床推广应用。Objective To explore the clinical effect of cetirizine combined with modified Xijiao Dihuang Decoction in the treatment of children with henoch schonlein purpura(blood heat and blood stasis syndrome).Methods 60 children with henoch schonlein purpura(blood heat and blood stasis syndrome)were selected as the study subjects and randomly divided into a control group and an observation group,with 30 cases in each group.The control group was given cetirizine treatment,and the observation group was given modified Xijiao Dihuang Decoction on the basis of the control group.The clinical efficacy,symptom remission time,recurrence rate and occurrence of adverse reactions were compared between the two groups.Results The total clinical effective rate of the observation group was 96.67%,which was higher than 73.33%of the control group,and the difference was statistically significant(P<0.05).The remission time of skin symptoms,joint symptoms and gastrointestinal symptoms in the observation group were(6.61±1.11),(3.18±0.68)and(11.46±2.25)d,which were shorter than(11.71±1.57),(7.77±1.39)and(20.21±4.27)d in the control group.The difference was statistically significant(P<0.05).The recurrence rate of 6.67%in the observation group was significantly lower than 30.00%in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was slightly lower than that in the control group,but the difference was not statistically significant(P>0.05).Conclusion Cetirizine combined with modified Xijiao Dihuang Decoction has significant clinical effect in the treatment of children with henoch schonlein purpura(blood heat and blood stasis syndrome),which can shorten the remission time of symptoms,reduce the recurrence rate,and have less adverse reactions,which is worthy of clinical promotion and application.

关 键 词：西替利嗪 加味犀角地黄汤 小儿过敏性紫癜 血热夹瘀证 临床效果 

分 类 号：R725.5[医药卫生—儿科]