鼻内镜术前应用枸地氯雷他定对慢性鼻窦炎的治疗效果研究  

Study on the effect of desloratadine citrate disodium in the treatment of chronic sinusitis before endoscopic sinus surgery

作　　者：杨慎友[1] 张佩佩 田长娜 YANG Shen-you;ZHANG Pei-pei;TIAN Chang-na(Jinxiang County People's Hospital,Jining 272200,China)

机构地区：[1]金乡县人民医院,272200

出　　处：《中国实用医药》2024年第10期48-52,共5页China Practical Medicine

摘　　要：目的 探讨鼻内镜术前应用枸地氯雷他定对慢性鼻窦炎的治疗效果。方法 220例慢性鼻窦炎患者,按随机数字表法分成对照组与研究组,各110例。两组均实施鼻内镜手术,研究组术前应用枸地氯雷他定,对照组术前未应用枸地氯雷他定。对比两组疗效、术后并发症发生率、术后恢复时间[鼻腔黏膜上皮化、鼻腔恢复通气及住院时间]、鼻腔黏液纤毛清除功能指标[鼻腔黏液纤毛清除速度、鼻腔黏液纤毛清除率、糖精清除时间]、血清炎性因子指标[C反应蛋白(CRP)、降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)]、生活质量评分。结果 研究组总有效率99.09%比对照组的92.73%高(P<0.05)。研究组术后并发症发生率1.82%比对照组的9.09%低(P<0.05)。研究组术后鼻腔黏膜上皮化、鼻腔恢复通气及住院时间分别为(8.03±1.82)周、(6.15±1.08)d、(7.09±1.23)d,均比对照组的(10.74±2.31)周、(7.69±1.34)d、(9.31±1.89)d短(P<0.05)。治疗后,两组鼻腔黏液纤毛清除速度、鼻腔黏液纤毛清除率、糖精清除时间均较治疗前显著改善,且研究组的鼻腔黏液纤毛清除速度(7.30±1.28)mm/min、鼻腔黏液纤毛清除率(76.39±11.87)%均比对照组的(5.92±1.49)mm/min、(61.18±10.91)%高,糖精清除时间(20.64±4.10)min比对照组的(27.35±4.38)min短(P<0.05)。治疗后,两组血清CRP、PCT、TNF-α对比于治疗前均明显降低,且研究组血清CRP(5.89±1.06)mg/L、PCT(0.46±0.15)ng/ml、TNF-α(10.83±2.07)ng/L均比对照组的(7.02±1.27)mg/L、(0.69±0.23)ng/ml、(13.49±2.46)ng/L低(P<0.05)。治疗后,两组生理、心理、环境及社会关系评分与治疗前相比均显著增高,且研究组生理、心理、环境及社会关系评分均较对照组高(P<0.05)。结论 在慢性鼻窦炎患者鼻内镜手术前应用枸地氯雷他定,可增强疗效,促使鼻腔黏膜尽快上皮化,还可增强患者鼻腔黏膜纤毛清除功能,减轻鼻腔炎症反应,减少术后并发症,有利于Objective To explore the effect of desloratadine citrate disodium in the treatment of chronic sinusitis before endoscopic sinus surgery.Methods 220 patients with chronic sinusitis were selected and divided into a control group and a study group according to random numerical table,with 110 cases in each group.Both groups underwent endoscopic sinus surgery.The study group received desloratadine citrate disodium before surgery,while the control group did not receive desloratadine citrate disodium before surgery.Both groups were compared in terms of efficacy,postoperative complication rate,postoperative recovery time[time of epithelialization of nasal mucosa,restoration of nasal ventilation and hospitalization],indexes of nasal mucociliary clearance function[nasal mucociliary clearance rate,mucociliary clearance rate,and saccharin clearance time],serum inflammatory factors[C-reactive protein(CRP),procalcitonin(PCT),tumor necrosis factor-α(TNF-α)]and quality of life.Results The total effective rate of the study group was 99.09%,which was higher than the control group's 92.73%(P<0.05).The incidence of postoperative complications was 1.82%in the study group,which was lower than the control group's 9.09%(P<0.05).The time of epithelialization of nasal mucosa,restoration of nasal ventilation and hospitalization in the study group were(8.03±1.82)weeks,(6.15±1.08)d and(7.09±1.23)d,which were shorter than(10.74±2.31)weeks,(7.69±1.34)d and(9.31±1.89)d in the control group(P<0.05).After treatment,the nasal mucociliary clearance rate,mucociliary clearance rate,and saccharin clearance time in both groups were significantly improved compared with those before treatment;the study group had nasal mucociliary clearance rate of(7.30±1.28)mm/min and mucociliary clearance rate of(76.39±11.87)%,which were higher than(5.92±1.49)mm/min and(61.18±10.91)%in the control group;the study group had shorter saccharin clearance time of(20.64±4.10)min than(27.35±4.38)min in the control group(P<0.05).After treatment,the serum CRP,PCT a

关 键 词：慢性鼻窦炎 鼻内镜手术 枸地氯雷他定 

分 类 号：R765.9[医药卫生—耳鼻咽喉科]