外泌体源性非编码RNA与腹膜透析超滤衰竭关系的研究进展  

Research progresses in the relationship between exosomal non-coding RNA and ultrafiltration failure in peritoneal dialysis

作　　者：陈晓晓 王路路 胡爽爽 马东红[1,2] CHEN Xiao-xiao;WANG Lu-lu;HU Shuang-shuang;MA Dong-hong(The First Ward District,Renal Disease Hospital,the First Affiliated Hospital of Xinxiang Medical College;Key Laboratory of Precise Treatment for Ultrafiltration Failure in Peritoneal Dialysis,Xinxiang City,Xinxiang 453000,China)

机构地区：[1]新乡医学院第一附属医院肾脏病医院一病区,新乡453000 [2]新乡市腹透超滤衰竭精准治疗重点实验室

出　　处：《中国血液净化》2024年第6期449-452,共4页Chinese Journal of Blood Purification

基　　金：河南省科技厅重点研发与推广项目(182102310585);河南省高等学校重点科研项目(17A320026);河南省卫生厅科技攻关省部共建备选项目(2018010013)。

摘　　要：外泌体是纳米级的细胞外囊泡,近年来在临床诊断和治疗开发中受到了国内外学者的广泛关注。非编码RNA包括微小RNA、环状RNA和长链非编码RNA等,在细胞或组织损伤时被动释放,与脂蛋白结合或被外泌体携带循环于各种体液中。本文对外泌体源性非编码RNA在腹膜透析超滤衰竭的研究做一综述,以期为临床中评估、预防超滤衰竭寻找潜在的治疗方法或生物标志物。Exosome is a nanoscale extracellular vesicle,which has recently attracted great attentions for the usefulness in clinical diagnosis and treatment both in China and in foreign countries.Non-coding RNA(ncRNA)includes tiny RNA,circular RNA,and long non-coding RNA,and others.ncRNA can be passively released during cellular and tissue damages,and binds to lipoproteins or circulates in various body fluids by exosome.This review focuses on the research progresses in exosomal ncRNA during ultrafiltration failure in peritoneal dialysis,in order to identify potential treatment methods and biomarkers for the clinical evaluation and prevention of ultrafiltration failure.

关 键 词：腹膜透析 超滤衰竭 外泌体 非编码RNA 

分 类 号：R459.5[医药卫生—治疗学]