注射用微交联透明质酸钠凝胶改善肤质的临床研究  

Clinical study on the improvement of skin texture with micro cross-linked hyaluronic acid for injection

作　　者：彭阳红 瞿绍军 郭煜娜 唐碧莹 李修运 PENG Yang-hong;QU Shao-jun;GUO Yu-na;TANG Bi-ying;LI Xiu-yun(So-Young Chengdu Internet Hospital,Sichuan Province,611130,China;Chengdu Wuhou Yililan Lake Medical Beauty Clinic,Sichuan Province,6110041,China)

机构地区：[1]成都新氧互联网医院,四川成都611130 [2]成都武侯伊丽兰湖医疗美容门诊部,四川成都610041

出　　处：《中国医疗美容》2024年第5期35-39,共5页China Medical Cosmetology

摘　　要：目的探究不同注射浓度的微交联透明质酸钠凝胶真皮内注射后改善肤质的有效性及安全性。方法招募46例女性志愿者,年龄23-37岁,随机分成两组,分别采用浓度5 mg/mL(A组)和6 mg/mL(B组)的微交联注射用交联透明质酸钠凝胶行面部真皮层内注射。分别在治疗前及治疗后1周、2周及1个月用MPA皮肤测试仪进行对比分析,同时术后随访患者满意度及并发症情况。结果46例患者顺利完成治疗及术后随访,44人完成术后常规检测,2人因出差无法完成术后检测。皮肤MPA检测分析显示A组相对于B组对各时间点肤颜色、光泽度及摩擦力的得分有正向作用(P=0.007,0.016,及0.023);而对于皮肤含水量得分两组透明质酸浓度未显示差异(P=0.141)。术后1月十分满意率调查显示,A组为81.82%,明显高于B组的25%(P=0.036)。术后并发症比较两组无统计学差异。结论面部真皮层低浓度注射微交联透明质酸钠凝胶对改善肤质有较好效果,受试者满意度较高、安全性较高,值得临床应用。Objective To explore the effectiveness and safety of micro cross-linked hyaluronic acid with different concentrations for improving skin texture after intradermal injection.Methods 46 female volunteers,aged from 23 to 37 years old,were recruited and randomly divided into two groups.The micro cross-linked hyaluronic acid for injection with a concentration of 5mg/mL(Group A)and 6mg/mL(Group B)were respectively used for facial intradermal injection.Comparative analysis was conducted using an MPA skin tester before and 1 week,2 weeks,and 1 month after treatment,and patient satisfaction and complications were followed up after treatment.Results All of 46 patients successfully completed treatment and follow-up,44 patients completed skin testing,and 2 patients was unable to complete testing due to business travel.The MPA skin tester showed that Group A had a positive effect on the skin color,glossiness,and friction at various time compared to Group B(P=0.007,0.016,and 0.023);However,there was no difference in HA concentration between the two groups in terms of skin moisture content score(P=0.141).The satisfaction rate survey one month after treatment showed that the Group A was 81.82%,signifificantly higher than the 25%in the Group B(P=0.036).There was no statistically signifificant difference in postoperative complications between the two groups.There was no difference in HA concentration(P=0.141).Conclusion The low concentration injection of micro cross-linked hyaluronic acid into the facial dermis has a good effect on improving the skin texture.The subjects have high satisfaction and safety,which is worthy of clinical application.

关 键 词：面部 中胚层治疗 微交联透明质酸 面部年轻化 

分 类 号：R62[医药卫生—整形外科]