A spotlight on dosage and subject selection for effective neuroprotection: exploring the central role of mitochondria  

作　　者：John Mitrofanis Jonathan Stone Michael R.Hamblin Pierre Magistretti Alim-Louis Benabid Glen Jeffery 

机构地区：[1]Fonds Clinatec,UniversitéGrenoble Alpes,Grenoble,France [2]School of Medical Science,University of Sydney,Sydney,Australia [3]Faculty of Health Sciences,University of Johannesburg,Johannesburg,South Africa [4]King Abdullah University of Science and Technology,Thuwal,Saudi Arabia [5]Institute of Ophthalmology,University College London,London,UK

出　　处：《Neural Regeneration Research》2025年第4期1081-1082,共2页中国神经再生研究（英文版）

基　　金：supported by Fonds Clinatec and COVEA France(to JM).

摘　　要：Neurons are notoriously vulnerable cell types.Even the slightest change in their internal and/or external environments will cause much distress and dysfunction,leading often to their death.A range of pathological conditions,including stroke,head trauma,and neurodegenerative disease,can generate stress in neurons,affecting their survival and proper function.In most neural pathologies,mitochondria become dysfunctional and this plays a pivotal role in the process of cell death.The challenge over the last few decades has been to develop effective interventions that improve neuronal homeostasis under pathological conditions.Such interventions,often referred to as disease-modifying or neuroprotective,have,however,proved frustratingly elusive,at both preclinical and,in particular,clinical levels.In this perspective,we highlight two factors that we feel are key to the development of effective neuroprotective treatments.These are:firstly,the choice of dose of intervention and method of application,and secondly,the selection of subjects,whether they be patients or the animal model.

关 键 词：protective DOSAGE DISTRESS 

分 类 号：R741[医药卫生—神经病学与精神病学]