Illuminating β-arrestin conformational dynamics by fluorine NMR  

作　　者：Bin Xia 

机构地区：[1]Beijing Nuclear Magnetic Resonance Center,College of Chemistry and Molecular Engineering,School of Life Sciences,Peking University,Beijing,100871,China

出　　处：《Magnetic Resonance Letters》2024年第2期73-74,共2页磁共振快报（英文）

摘　　要：In a recent paper, solution-state ^(19)F NMR spectroscopy was used to probe the conformational dynamics of β-arrestin-1, an essential adaptor and signaling component of the G-protein couple receptor (GPCR) signaling pathway. This work reveals a highly complex conformational energy landscape of β-arrestin-1, and illuminates the molecular mechanism of the membrane phosphoinositide PIP2-induced β-arrestin-1 activation at residue level.(https://doi.org/10.1038/s41467-023-43694-1).

关 键 词：conformational DYNAMICS FLUORINE 

分 类 号：O482.532[理学—固体物理] Q617[理学—物理]