电雾式检测器的研究进展及在药物领域中的应用  

Progress in Charged Aerosol Detector and Its Applications in Pharmaceutical Analysis

作　　者：邹晓伟 刘星 杨佩华 张建明 ZOU Xiaowei;LIU Xing;YANG Peihua;ZHANG Jianming(Shanghai Kezhe Biochemical Technology Co.Ltd.,Shanghai 201108,China)

机构地区：[1]上海科哲生化科技有限公司,上海201108

出　　处：《分析测试技术与仪器》2024年第3期172-188,共17页Analysis and Testing Technology and Instruments

摘　　要：液相色谱搭配紫外检测器系统是药物检测中最常使用的分析仪器之一,在大多数情况下能够应对各种分析任务.然而在实际应用中,常会遇到待测成分没有紫外吸收的情形,这时其他响应机制的检测器往往能起到很好的检测效果.其中,电雾式检测器(CAD)近年来倍受青睐.简要介绍了CAD的机理和仪器结构,对比了CAD与其他类型气溶胶类检测器间的异同,汇总了近年来CAD在药物分析领域中的应用,最后展望了CAD未来的发展.The liquid chromatograph with UV detector system is one of the most commonly used analytical instruments in pharmaceutical analysis,which can deal with most analytical tasks.However,the analytes without UV spectral absorption are often encountered in practical applications,when other detectors with different response mechanisms as supplements might achieve good results.The charged aerosol detector(CAD)have been widely used in recent years.The mechanism and instrument structure of CAD were briefly introduced.The similarities and differences between CAD and other aerosol-based detectors were compared.The applications of CAD in the field of pharmaceutical analysis in recent years were summarized and finally the future development of the detector were prospected.

关 键 词：电雾式检测器 气溶胶类检测器 药物检测 

分 类 号：O657.72[理学—分析化学] TQ460.72[理学—化学]