血小板衍生生长因子BB参与生长板损伤修复的作用与机制  

Role and mechanism of platelet-derived growth factor BB in repair of growth plate injury

作　　者：彭洪成 彭国璇 雷安毅 林圆 孙红 宁旭 尚显文 邓进 黄明智 Peng Hongcheng;Peng Guoxuan;Lei Anyi;Lin Yuan;Sun Hong;Ning Xu;Shang Xianwen;Deng Jin;Huang Mingzhi(Department of Orthopedics,Affiliated Hospital of Guizhou Medical University,Guiyang 550004,Guizhou Province,China;Clinical Medicine School of Guizhou Medical University,Guiyang 550004,Guizhou Province,China;Department of Emergency Medicine,Affiliated Hospital of Guizhou Medical University,Guiyang 550004,Guizhou Province,China)

机构地区：[1]贵州医科大学附属医院骨科,贵州省贵阳市550004 [2]贵州医科大学临床医学院,贵州省贵阳市550004 [3]贵州医科大学附属医院急诊医学科,贵州省贵阳市550004

出　　处：《中国组织工程研究》2025年第7期1497-1503,共7页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金项目(82360420),项目负责人:彭国璇;贵州医科大学附属医院博士科研启动基金项目(gyfybskj-2023-07),项目负责人:彭国璇;贵州省卫生健康委员会科技项目(GZWJKJXM20240939),项目负责人:彭国璇;贵州省科技计划项目(黔科合基础-ZK[2023]一般387),项目负责人:黄明智。

摘　　要：背景:在生长板损伤炎症初期,血小板衍生生长因子BB通过促进间充质祖细胞浸润、软骨形成、成骨反应以及调控骨重塑来促进生长板损伤的修复。目的:总结血小板衍生生长因子BB在生长板损伤修复中的作用机制。方法:检索PubMed、维普、万方数据和中国知网数据库,中文检索词为“生长板损伤,骨桥形成,血小板衍生因子BB,修复”,英文检索词为“growth plate injury,bone bridge,PDGF-BB,repair”,最终筛选66篇文章进行综述。结果与结论:生长板损伤经历早期炎症、血管重建、纤维骨化、结构重塑等病理进程,伴随着软骨细胞、血管内皮细胞、干细胞、成骨细胞、破骨细胞多种细胞交叉对话。血小板衍生生长因子BB作为损伤早期炎症反应的重要因子通过介导多种细胞炎症反应调控损伤修复过程,靶向血小板衍生生长因子BB介导的炎症刺激可能通过改善破骨细胞、成骨细胞、软骨细胞功能活性延缓生长板损伤骨桥形成进程,实现生长板损伤修复。血小板衍生生长因子BB对生长板损伤部位的血管生成和骨修复组织形成以及未损伤生长板的软骨内骨延长功能具有重要作用,抑制血小板衍生生长因子BB启动的血管形成与软骨内成骨之间的偶联效应将有可能实现生长板损伤修复。BACKGROUND:In the initial stage of growth plate injury inflammation,platelet-derived growth factor BB promotes the repair of growth plate injury by promoting mesenchymal progenitor cell infiltration,chondrogenesis,osteogenic response,and regulating bone remodeling.OBJECTIVE:To elucidate the action mechanism of platelet-derived growth factor BB after growth plate injury.METHODS:PubMed,VIP,WanFang,and CNKI databases were used as the literature sources.The search terms were“growth plate injury,bone bridge,plateletderived growth factor BB,repair”in English and Chinese.Finally,66 articles were screened for this review.RESULTS AND CONCLUSION:Growth plate injury experienced early inflammation,vascular reconstruction,fibroossification,structural remodeling and other pathological processes,accompanied by the crosstalk of chondrocytes,vascular endothelial cells,stem cells,osteoblasts,osteoclasts and other cells.Plateletderived growth factor BB,as an important factor in the early inflammatory response of injury,regulates the injury repair process by mediating a variety of cellular inflammatory responses.Targeting the inflammatory stimulation mediated by platelet-derived growth factor BB may delay the bone bridge formation process by improving the functional activities of osteoclasts,osteoblasts,and chondrocytes,so as to achieve the injury repair of growth plate.Plateletderived growth factor BB plays an important role in angiogenesis and bone repair tissue formation at the injured site of growth plate and intrachondral bone lengthening function of uninjured growth plate.Inhibition of the coupling effect between angiogenesis initiated by platelet-derived growth factor BB and intrachondral bone formation may achieve the repair of growth plate injury.

关 键 词：生长板损伤 骨桥 血小板衍生生长因子BB 软骨再生 综述 

分 类 号：R459.9[医药卫生—治疗学] R319[医药卫生—临床医学] R-1