Platelet-derived microparticles and their cargos: The past, present and future  

作　　者：Jingwen Guo Bufeng Cui Jie Zheng Chang Yu Xuran Zheng Lixin Yi Simeng Zhang Keke Wang 

机构地区：[1]Department of Pharmacy,The First Hospital of China Medical University,Shenyang 110001 China [2]School of Pharmacy,China Medical University,Shenyang 110122,China [3]Key Laboratory of Medical Cell Biology of Ministry of Education,Key Laboratory of Major Chronic Diseases of Nervous System of Liaoning Province,Health Sciences Institute of China Medical University,Shenyang 110122,China [4]Department of Pharmacy,The Fourth Affiliated Hospital of China Medical University,Shenyang 110032,China [5]Department of Medical Oncology,the First Hospital of China Medical University,Shenyang 110001,China

出　　处：《Asian Journal of Pharmaceutical Sciences》2024年第2期72-88,共17页亚洲药物制剂科学（英文）

基　　金：supported by the National Science Fund for Distinguished Young Scholars(No:81901099 and 81703427);the 64th batch of China Postdoctoral Science Foundation(No:2018M641731).

摘　　要：All eukaryotic cells can secrete extracellular vesicles, which have a double-membrane structure and are important players in the intercellular communication involved in a variety of important biological processes. Platelets form platelet-derived microparticles (PMPs) in response to activation, injury, or apoptosis. This review introduces the origin, pathway, and biological functions of PMPs and their importance in physiological and pathological processes. In addition, we review the potential applications of PMPs in cancer, vascular homeostasis, thrombosis, inflammation, neural regeneration, biomarkers, and drug carriers to achieve targeted drug delivery. In addition, we comprehensively report on the origin, biological functions, and applications of PMPs. The clinical transformation, high heterogeneity, future development direction, and limitations of the current research on PMPs are also discussed in depth. Evidence has revealed that PMPs play an important role in cell-cell communication, providing clues for the development of PMPs as carriers for relevant cell-targeted drugs. The development history and prospects of PMPs and their cargos are explored in this guidebook.

关 键 词：Platelet-derived particles Application Heter ogeneity Potential and limitations 

分 类 号：R392-33[医药卫生—免疫学]