六氟环氧丙烷三聚体羧酸(HFPO-TA)污染现状和生物毒性研究进展  

A review of contamination status and and biotoxicity of hexafluoropropylene oxide trimer acid(HFPO-TA)

作　　者：刘梦琳 王冰菁 宿琪 索秉旭 冯精兰 余浩 LIU Menglin;WANG Bingjing;SU Qi;SUO Bingxu;FENG Jinglan;YU Hao(School of Environment,Key Laboratory for Yellow River and Huai River Water Environment and Pollution Control,Ministry of Education,Henan Key Laboratory for Environmental Pollution Control,International Joint Laboratory on Key Techniques in Water Treatment,Henan Normal University,Xinxiang,453007,China)

机构地区：[1]河南师范大学环境学院,黄淮水环境污染与防治教育部重点实验室,河南省环境污染控制重点实验室,水处理关键技术国际联合实验室,新乡453007

出　　处：《环境化学》2024年第5期1415-1428,共14页Environmental Chemistry

基　　金：国家自然科学基金青年科学基金(42207427);中国博士后科学基金(2022M711071);河南师范大学博士科研启动基金(5101219170833);河南师范大学博士后科研启动基金(5101219470248)资助.

摘　　要：全氟/多氟化合物(per-and polyfluoroalkyl substances,PFAS)是一类具有优良表面活性和稳定性的有机化合物,广泛应用于工业和消费领域,全氟辛烷羧酸(perfluorooctanoic acid,PFOA)是具有代表性的一类PFAS.由于具有持久性、生物蓄积性、长距离迁移和生物毒性,PFOA已被限制生产和使用.六氟环氧丙烷三聚体羧酸(hexafluoropropylene oxide trimer acid,HFPO-TA)是一类新型的PFOA替代品.HFPO-TA在全球范围内的环境介质中广泛存在,在一些介质中的浓度接近甚至高于PFOA.HFPOTA能在生物体内蓄积并可产生生物毒性效应,由于其独特的化学结构和理化性质,HFPO-TA的生物积累潜能和生物毒性强于PFOA.本文从HFPO-TA的生产、用途、环境归趋、环境介质和生物体内的污染现状、生物毒性和降解进行综述,并对未来研究趋势和发展方向进行展望,为研究HFPO-TA在生物体内富集与转化机制和毒理学评价提供参考依据.Per-and polyfluoroalkyl substances(PFAS)are a class of organic compounds with excellent surface activity and stability,which are widely used in industrial and consumer fields.Perfluorooctanoic acid(PFOA)is a representative class of PFAS.Duo to its persistence,bioaccumulation,long-distance migration and biological toxicity,PFOA has been restricted in production and use.Hexafluoropropylene oxide trimer acid(HFPO-TA)is a novel alternative to PFOA.HFPO-TA is widely distributed in environmental around the word,and its concentration in some media is close to or even higher than PFOA.HFPO-TA can accumulate in organisms and lead to biological toxicity.Due to its unique chemical structure and physical and chemical properties,HFPO-TA has stronger bioaccumulation potential and biological toxicity than PFOA.In this paper,the production,use,environmental fate,the pollution status in environmental medium and organisms,biotoxicity and degradation of HFPO-TA are reviewed,and the future research trend and development direction are prospected,providing reference basis for the study of enrichment and transformation mechanism of HFPO-TA in organisms and toxicological evaluation.

关 键 词：六氟环氧丙烷三聚体羧酸 多介质分布 生物富集 生物毒性 降解 

分 类 号：X-1[环境科学与工程] O6[理学—化学]