过氧化物酶体增殖活化因子受体γ及其激动剂在类风湿关节炎中的作用研究进展  

Research progress in the role of peroxisome proliferator-activated receptor-γand its agonists in rheumatoid arthritis

作　　者：陈娜 臧雷 刘芳 CHEN Na;ZANG Lei;LIU Fang(Department of Pharmacy,First Affiliated Hospital of Army Medical University of Chinese People’s Liberation Army,Chongqing 400038)

机构地区：[1]中国人民解放军陆军军医大学第一附属医院药剂科,重庆400038

出　　处：《中南药学》2024年第5期1311-1316,共6页Central South Pharmacy

基　　金：重庆市自然科学基金项目(No.CSTB2022NSCQ-MSX0202);重庆市科卫联合中医药项目(2019ZY023488)。

摘　　要：类风湿关节炎是一种以多关节滑膜炎为主要特征的自身免疫性疾病,其发病机制尚未完全阐明。过氧化物酶体增殖活化因子受体γ(PPARγ)是一类配体激活的核转录因子超家族成员,在免疫调节、炎症控制和骨稳定中发挥重要功能。因此,研究PPARγ在类风湿关节炎中发挥的作用具有重要意义。本文就PPARγ在类风湿关节炎中的作用进行综述,并讨论基于PPARγ靶点治疗药物的发展情况,以期为抗类风湿关节炎新药研发提供思路和参考。Rheumatoid arthritis is an autoimmune disease characterized by polyarticular synovitis,whose pathogenesis has not been fully elucidated.Peroxisome proliferator-activated receptor-γ(PPARγ)is a member of the ligand-activated nuclear transcription factor superfamily,which plays an important role in immune regulation,inflammation control and bone stability.It is important to determine the role of PPARγin rheumatoid arthritis.This article reviewed the role of PPARγin rheumatoid arthritis,and the development of therapeutic drugs based on the target of PPARγ,so as to provide reference for the development of new drugs for rheumatoid arthritis.

关 键 词：类风湿关节炎 过氧化物酶体增殖活化因子受体γ 炎症控制 免疫调节 骨稳定 

分 类 号：R593.22[医药卫生—内科学]