术前血清Lp-PLA2与NLRP3水平对IABP辅助PCI治疗的高危冠心病患者发生MACE的预测价值  

The Predictive Value of Preoperative Serum Lp-PLA2 and NLRP3 Levels for MACE in High-Risk Coronary Heart Disease Patients Treated with IABP Assisted PCI

作　　者：王涛[1] 邹永辉[1] 杨蕾 WANG Tao;ZOU Yonghui;YANG Lei(Zhengzhou First People's Hospital,Zhengzhou Henan 450000)

机构地区：[1]郑州市第一人民医院,河南郑州450000

出　　处：《医学临床研究》2024年第5期700-703,共4页Journal of Clinical Research

摘　　要：【目的】探讨术前血清脂蛋白相关磷脂酶A2(Lp-PLA2)与核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)水平对主动脉内球囊反搏(IABP)辅助经皮冠状动脉介入治疗(PCI)高危冠心病患者发生心血管不良事件(MACE)的预测价值。【方法】选取本院收治的120例高危冠心病患者,所有患者均行IABP辅助PCI治疗。统计术后6个月内MACE发生情况,分为非MACE组和MACE组,比较两组术前血清Lp-PLA2、NLRP3水平,分析术前血清Lp-PLA2、NLRP3水平与冠脉狭窄程度的相关性,采用受试者工作特征(ROC)曲线分析术前血清Lp-PLA2、NLRP3水平预测术后发生MACE的价值。【结果】120例IABP辅助PCI术后高危冠心病患者MACE发生率为34.17%(41/120);MACE组术前血清Lp-PLA2、NLRP3水平均高于非MACE组(P<0.05)。Spearman相关性分析显示,术前血清Lp-PLA2、NLRP3水平与冠脉狭窄程度呈正相关(r_(s)=0.750、0.815,均P<0.05)。重度患者术前血清Lp-PLA2、NLRP3水平高于中度、轻度患者,中度患者高于轻度患者(P<0.05)。ROC曲线分析显示,术前血清Lp-PLA2、NLRP3水平单独预测的曲线下面积分别为0.770、0.844,二者联合预测AUC为0.909(P<0.05)。【结论】术前血清Lp-PLA2、NLRP3水平与高危冠心病患者冠脉狭窄程度呈正相关,二者联合检测可为临床预测高危冠心病患者IABP辅助PCI手术治疗后发生MACE提供一定参考依据。【Objective】To explore the predictive value of preoperative serum lipoprotein associated phospholipase A2(Lp-PLA2)and nucleotide binding oligomeric domain like receptor protein 3(NLRP3)levels for cardiovascular adverse events(MACE)in high-risk coronary heart disease patients undergoing intra-aortic balloon counterpulsation(IABP)assisted percutaneous coronary intervention(PCI).【Methods】A total of 120 high-risk coronary heart disease patients admitted to our hospital were selected and all underwent IABP assisted PCI treatment.The incidence of MACE within 6 months after surgery was statistically analyzed and divided into the non MACE group and the MACE group.The preoperative serum Lp-PLA2 levels were compared between the two groups NLRP3 level.The correlation between preoperative serum Lp-PLA2 and NLRP3 levels and the degree of coronary stenosis were analyzed.The receiver operating characteristic(ROC)curve was used to analyze the value of preoperative serum Lp-PLA2 and NLRP3 level in predicting postoperative MACE.【Results】The incidence of MACE in 120 high-risk coronary heart disease patients after IABP assisted PCI was 34.17%(41/120);Preoperative serum Lp-PLA2 in the MACE group The levels of NLRP3 were higher than those in the non MACE group(P<0.05).Spearman correlation analysis showed that preoperative serum Lp-PLA2 The level of NLRP3 was positively correlated with the degree of coronary stenosis(r_(s)=0.750,0.815,all P<0.05).The level of preoperative serum Lp-PLA2 and NLRP3 in severe patients was higher those in moderate and mild patients,with moderate patients having higher levels than mild patients(P<0.05).ROC curve analysis showed that the area under the curve predicted by preoperative serum Lp-PLA2 and NLRP3 level alone was 0.770 and 0.844,respectively.The joint prediction of AUC by the two was 0.909(P<0.05).【Conclusion】The level of Preoperative serum Lp-PLA2 and NLRP3 was positively correlated with the degree of coronary artery stenosis in high-risk coronary heart disease patients.The combined

关 键 词：冠心病 1-烷基-2-乙酰甘油磷酸胆碱酯酶/血液 NLR家族 热蛋白结构域包含蛋白3/血液 经皮冠状动脉介入治疗 

分 类 号：R541.4[医药卫生—心血管疾病]