西沙必利联合血液灌流对CRF维持性血液透析患者胃肠道症状及胃肠激素水平的影响  

The Effect of Cisapride Combined with Hemoperfusion on Gastrointestinal Symptoms and Gastrointestinal Hormone Levels in CRF Maintenance Hemodialysis Patients

作　　者：王东南 杨静 贾转曌 WANG Dongnan;YANG Jing;JIA Zhuanzhao(Xuchang People's Hospital,Xuchang Henan 461000)

机构地区：[1]许昌市人民医院,河南许昌461000

出　　处：《医学临床研究》2024年第5期732-735,共4页Journal of Clinical Research

摘　　要：【目的】探讨西沙必利辅助血液灌流对慢性肾衰竭(CRF)维持性血液透析患者胃肠道症状及胃肠激素水平的影响。【方法】回顾性分析2021年2月至2023年1月本院收治的72例CRF患者的临床资料,根据治疗方法不同将其分为观察组和对照组,每组36例。两组均行维持性血液透析治疗,对照组予以血液灌流治疗,观察组在对照组的基础上予以西沙必利治疗。治疗2周后,比较两组肾功能[血肌酐(Scr)、尿素氮(BUN)、肾小球滤过率(GFR)]、胃肠道症状、胃肠激素[生长抑素(SS)、胃动素(MOT)、血管活性肠肽(VIP)]及血清成纤维细胞生长因子23(FGF-23)、降钙素基因相关肽(CGRP)、肿瘤坏死因子-α(TNF-α)水平及不良反应发生情况。【结果】治疗后,两组Scr、BUN均较治疗前降低,eGER均较治疗前升高(P<0.05);两组Scr、BUN、eGER比较,差异无统计学意义(P>0.05)。治疗后,两组反酸、恶心及呕吐、腹胀、嗳气、便秘评分均低于治疗前,且观察组低于对照组(P<0.05)。治疗后,观察组血清MOT、SS水平低于治疗前及对照组,VIP高于治疗前及对照组(P<0.05)。治疗后,两组血清FGF-23、CGRP、TNF-α水平低于治疗前,且观察组低于对照组(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。【结论】西沙必利辅助血液灌流治疗CRF维持性血液透析患者,可调节胃肠激素水平,改善胃肠道症状,减轻炎症损伤,安全性较高。【Objective】To explore the effects of cisapride assisted blood perfusion therapy on gastrointestinal symptoms and gastrointestinal hormone levels in maintenance hemodialysis patients with chronic renal failure(CRF).【Methods】A retrospective analysis was conducted on the clinical data of 72 patients with CRF admitted to our hospital from February 2021 to January 2023.According to the treatment method,they were divided into an observation group and a control group,with 36 cases in each group.Both groups received maintenance hemodialysis treatment,the control group received hemoperfusion treatment,and the observation group received cisapride treatment on the basis of the control group.After 2 weeks of treatment,renal function(Scr),urea nitrogen(BUN),glomerular filtration rate(GFR),gastrointestinal symptoms,gastrointestinal hormones[somatostatin(SS),motilin(MOT),vasoactive intestinal peptide(VIP)],serum fibroblast growth factor 23(FGF-23),calcitonin gene related peptide(CGRP),tumor necrosis factor alpha(TNF-α)levels,and incidence of adverse reactions were compared between the two groups.【Results】After treatment,Scr and BUN of two groups decreased compared to before treatment,EGER increased compared to that before treatment(P<0.05);There was no statistically significant difference between Scr,BUN and eGER in the two sets(P>0.05).After treatment,the scores of acid reflux,nausea and vomiting,bloating,belching,and constipation in both groups were lower than those before treatment,and the observation group was lower than the control group(P<0.05).After treatment,The level of serum MOT and SS in the observation group was lower than that before treatment and that in the control group,VIP was higher than that before treatment and that in the control group(P<0.05).After treatment,The levels of serum FGF-23 CGRP and TNF-αin two groups were lower than those before treatment,and the observation group was lower than the control group(P<0.05).The incidence of adverse reactions in the observation group was lower than th

关 键 词：肾功能衰竭 慢性 西沙必利/治疗应用 肾透析 血液灌注 胃肠激素类/血液 

分 类 号：R692.5[医药卫生—泌尿科学]