白介素-1家族在心力衰竭中的作用研究进展  

Research progress of interleukin-1 family in heart failure

作　　者：杨培丽 路美娟[2] YANG Peili;LU Meijuan(Graduate School,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学研究生院,天津市301617 [2]天津中医药大学第二附属医院心血管内科

出　　处：《河北医药》2024年第11期1710-1714,共5页Hebei Medical Journal

基　　金：天津市教委科研计划自然重点项目(编号:2021ZD028)。

摘　　要：炎性反应是决定心力衰竭(HF)严重程度和预后的关键因素,以IL-1、IL-18和IL-33/ST2轴为主的白介素(IL)-1家族细胞因子通过介导多种信号通路参与炎性反应,导致心肌收缩与舒张功能障碍、心脏重构、线粒体功能障碍及血管异常损伤,本文HF各个生理病理环节中发挥关键作用。现就IL-1、IL-18和IL-33/ST2轴在HF炎性反应中的作用机制的最新研究进展作一综述。Inflammatory response is a key factoRin determining the severity and prognosis of heart failure(HF).Interleukin(IL)-1 family cytokines,mainly including IL-1,IL-18 and IL-33/suppression of tumorigenicity 2(ST2)axis,participate in inflammation through mediating various signaling pathways,leading to myocardial systolic and diastolic dysfunction,cardiac remodeling,mitochondrial dysfunction and abnormal vasculaRinjury.IL-1 family plays a key role in each physiological and pathological link of HF.This article reviewed the mechanism of action of IL-1,IL-18 and IL-33/ST2 axis in HF-induced inflammation.

关 键 词：心力衰竭 IL-1 IL-18 IL-33/ST2 炎症 

分 类 号：R541.6[医药卫生—心血管疾病]