HIV/AIDS病例HIV相关神经认知障碍的影响因素分析  

Influencing factors for HIV-associated neurocognitive disorders among HIV/AIDS patients

作　　者：贾晓锋 王慧群 石敏[2] 汤婕 任静霞 JIA Xiaofeng;WANG Huiqun;SHI Min;TANG Jie;REN Jingxia(School of Nursing,Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210003,China;Nanjing Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210037,China)

机构地区：[1]南京中医药大学护理学院,江苏南京210003 [2]南京中医药大学附属南京医院,江苏南京210037

出　　处：《预防医学》2024年第6期461-464,共4页CHINA PREVENTIVE MEDICINE JOURNAL

基　　金：2023年江苏省研究生培养创新工程研究生科研与实践创新计划项目(SJCX23_0823)。

摘　　要：目的探讨艾滋病病毒感染者和艾滋病患者(HIV/AIDS)HIV相关神经认知障碍(HAND)的影响因素,为制定HAND预防措施提供依据。方法选择南京市第二医院感染科门诊就诊的≥18岁HIV/AIDS病例为研究对象,收集人口学信息、治疗方案和血生化指标等资料,采用患者健康问卷抑郁量表调查抑郁情绪,采用中文版Tilburg衰弱指数量表调查衰弱状况,采用蒙特利尔认知评估量表评估HAND;采用多因素logistic回归模型分析HAND的影响因素。结果发放问卷440份,回收有效问卷426份,问卷有效率为96.82%。调查男性407例,占95.54%;年龄M(QR)为33.00(10.00)岁;本科及以上学历232例,占54.46%。检出HAND 171例,检出率为40.14%。多因素logistic回归分析结果显示,文化程度(本科及以上,OR=0.291,95%CI:0.157~0.541)、抑郁情绪(OR=2.499,95%CI:1.530~4.083)、衰弱(OR=2.121,95%CI:1.307~3.441)和治疗方案含有依非韦伦(OR=2.223,95%CI:1.367~3.615)是HIV/AIDS病例发生HAND的影响因素。结论HIV/AIDS病例HAND发生风险可能与文化程度、抑郁情绪、衰弱和使用依非韦伦治疗有关。Objective To explore the factors affecting the prevalence of HIV-associated neurocognitive disorders(HAND)among HIV/AIDS patients,so as to provide insights into developing HAND prevention measures.Methods HIV/AIDS patients aged 18 years and above in the Infection Department of Nanjing Second Hospital were selected.Demographic data,treatment regimen and blood biochemical indicators were collected.Depression was evaluated using Patient Health Questionnaire Depression Scale,frailty was evaluated using Chinese version of Tilburg Frailty Indicator,and HAND was evaluated by Montreal Cognitive Assessment Scale.Factors affecting HAND were analyzed using a multivariable logistic regression model.Results Totally 440 questionnaires were allocated and 426 valid questionnaires were recovered,with an effective rate of 96.82%.The median age of patients investigated was 33.00(interquartile range,10.00)year.There were 407 males,accounting for 95.54%;232 patients with bachelor degree or above,accounting for 54.46%;171 patients with HAND,accounting for 40.14%.Multivariable logistic regression analysis showed that educational level(bachelor degree or above,OR=0.291,95%CI:0.157-0.541),depression(OR=2.499,95%CI:1.530-4.083),frailty(OR=2.121,95%CI:1.307-3.441)and treatment regimen including efavirenz(OR=2.223,95%CI:1.367-3.615)were the influencing factors for HAND among HIV/AIDS patients.Conclusion Educational level,depression,frailty and use of efavirenz may be associated with HAND risk.

关 键 词：艾滋病病毒 神经认知障碍 影响因素 

分 类 号：R512.91[医药卫生—内科学]