超早产儿获得性巨细胞病毒感染的临床检测及分析  

Clinical detection and analysis of acquired cytomegalovirus infection in extremely preterm infants

作　　者：张燕[1] 张虹 王彦云[1] ZHANG Yan;ZHANG Hong;WANG Yanyun(Center for Newborn Screening,Women′s Hospital of Nanjing Medical University,Nanjing Maternity and Child Health Care Hospital,Nanjing 210004,Jiangsu,China)

机构地区：[1]南京医科大学附属妇产医院/南京市妇幼保健院新生儿筛查中心,南京210004

出　　处：《临床检验杂志》2024年第5期348-351,共4页Chinese Journal of Clinical Laboratory Science

基　　金：南京市卫生局课题(YKK19118);江苏省妇幼健康项目(F202161);宿迁市卫生局课题(Z2021070)。

摘　　要：目的探讨获得性巨细胞病毒感染在超早产儿中的临床应用价值。方法回顾性分析本院新生儿科2023年7月1日至9月15日送检的1072例新生儿血清样本的巨细胞病毒相关抗体检测结果。结果1072例样本中有2例患儿确诊获得性巨细胞病毒感染。该2例患儿均为超早产儿(胎龄24~27+6周)、超低出生体重儿(750~999 g),均以血小板降低为首发表现,1例为输血获得性巨细胞病毒感染,另1例为母乳获得性巨细胞病毒感染。结论在超早产儿这类特殊人群中,输血治疗时需警惕输血获得性巨细胞病毒感染,同时也要谨防母乳获得性巨细胞病毒感染,必要时经巴氏消毒后再喂养。Objective To analyze the clinical characteristics of acquired cytomegalovirus infection in extremely preterm infants.Methods The detection results of cytomegalovirus related antibodies in serum samples from 1072 newborns in the Department of Neonatology of our hospital from July 1,2023 to September 15,2023 were retrospectively analyzed.Results Among the 1072 newborns,2 were diagnosed with acquired cytomegalovirus infection.The two newborns were extremely preterm infants(24-27+6 weeks of gestational age)and extremely low birth weight infants(750-999 g).They presented with thrombocytopenia as the initial manifestation.One case was a transfusion-acquired cytomegalovirus infection and the other was a breast milk-acquired cytomegalovirus infection.Conclusion In special populations such as extremely preterm infants,it is necessary to prevent transfusion-acquired cytomegalovirus infection during transfusion therapy,as well as breast milk-acquired cytomegalovirus infection.If necessary,pasteurization should be used before feeding.

关 键 词：巨细胞病毒 输血获得性巨细胞病毒感染 辐照红细胞 超早产儿 超低出生体重儿 

分 类 号：R446[医药卫生—诊断学]