尺寸可控有机杂化二氧化硅胶体粒子的制备  

Preparation of Size-controlled OrganicHybrid Silica Colloidal Particles

作　　者：任宇航 邹华[1] REN Yuhang;ZOU Hua(School of Materials and Chemistry,University of Shanghai for Science and Technology,Shanghai 200093,China)

机构地区：[1]上海理工大学材料与化学学院,上海200093

出　　处：《合成化学》2024年第6期562-568,共7页Chinese Journal of Synthetic Chemistry

摘　　要：有机杂化二氧化硅胶体粒子因其独特的性质被广泛地应用于生物医学领域。对于不同的器官组织,纳米粒子的尺寸不同,因而尺寸可控的有机杂化二氧化硅胶体粒子在生物医学应用中尤为重要。以乙烯基三甲氧基硅烷(VTMS)为硅烷前驱体,氢氧化铵为催化剂,通过硅烷前驱体在碱性条件下自发形成乳液,然后由引发剂过硫酸铵(APS)引发聚合来制备尺寸可控的有机杂化二氧化硅胶体粒子。采用场发射扫描电子显微镜和ImageJ软件,探究了引发剂种类、前驱体浓度、氢氧化铵浓度以及乳化时间等不同条件对有机杂化二氧化硅胶体粒子尺寸的影响。结果表明:前驱体浓度增大会造成有机杂化二氧化硅胶体粒子的尺寸增大,而氢氧化铵浓度增大则起到相反的作用。随着乳化时间延长,有机杂化二氧化硅胶体粒子的尺寸先减小后增大。Organic hybrid silica colloidal particles are widely used in the field of biomedicine due to their unique properties. The size of nanoparticles required for different organs tissues is also different.Therefore, size-controllable organic hybrid silica colloidal particles play a crucial role in biomedical applications. In this paper, vinyltrimethoxysilane(VTMS) was used as the precursor of silane, and ammonium hydroxide was used as the catalyst. Size-controlled organic hybrid silica colloidal particles were prepared by the spontaneous emulsification of the silane precursor under alkaline conditions, followed by polymerization initiated by ammonium persulfate(APS). The effects of different conditions, such as the type of initiator, precursor concentration, ammonium hydroxide concentration, and emulsification time, on the size of the organic hybrid silica colloidal particles were investigated using field emission scanning electron microscopy and ImageJ software. The results showed that an increase in precursor concentration led to an increase in the size of the organic hybrid silica colloidal particles, while an increase in ammonium hydroxide concentration had the opposite effect.

关 键 词：硅烷自发乳化 乙烯基三甲氧基硅烷 氢氧化铵 尺寸可控 有机杂化二氧化硅胶体粒子 

分 类 号：O69[理学—化学]