氮杂环卡宾与过渡金属协同催化反应研究进展  

Research Progress on The Cooperative Catalytic Reaction ofNitrogen Heterocyclic Carbenes and Transition Metals

作　　者：武沛 王博 丁雅丽 王苗苗 WU Pei;WANG Bo;DING Yali;WANG Miaomiao(China Nuclear Power Engineering Co.,Ltd.,Beijing 100840,China;School of Chemistry and Chemical Engineering,Qinghai Nationalities University,Xining 810007,China;Beijing Huiwen Experimental Middle School,Beijing 100005,China)

机构地区：[1]中国核电工程有限公司,北京100840 [2]青海民族大学化学化工学院,青海西宁810007 [3]北京汇文实验中学,北京100005

出　　处：《合成化学》2024年第6期569-586,共18页Chinese Journal of Synthetic Chemistry

基　　金：青海民族大学高层次人才项目(2021XJG16)。

摘　　要：在有机化学反应中,过渡金属和有机小分子催化剂联合催化反应为构建复杂结构分子提供了强有力的策略。根据催化剂的作用方式以及加料的顺序不同,可分为协同催化、串联/序列催化。随着对氮杂环卡宾催化反应的不断深入研究,氮杂环卡宾与Br?nsted酸/碱,Lewis酸串联/序列催化或协同催化得到了迅速发展,实现了反应选择性、对映选择性及非对映选择性的精准调控。目前,氮杂环卡宾在与钯、钛、铜和钌等过渡金属协同催化反应中取得了重要进展,该类反应可被用于一些手性活性分子、生物医药小分子等骨架的构建,具有潜在的应用价值及发展前景。In organic synthesis, the combined catalysis of transition metals and organic molecules provide a powerful strategy for constructing complex structured molecules. According to the different mechanism of catalysts and the order of feeding, the reaction can be divided into cooperative catalysis and cascade/sequential catalysis. In depth research on the catalytic reactions of nitrogen heterocyclic carbenes, the cascade/sequential or cooperative catalysis of nitrogen heterocyclic carbenes with Br nsted acids/bases, Lewis acids, has developed rapidly, and has achieved precise regulation of reaction selectivity, enantioselectivity, and diastereoselectivity. At present, nitrogen heterocyclic carbenes have made significant progress in cooperative catalytic reactions with transition metals such as palladium, titanium, copper, and ruthenium. This type of reaction can be used for the construction of some chiral active molecules, biomedicine small molecules, and other skeletons, with potential application value and development prospects.

关 键 词：过渡金属 氮杂环卡宾 协同催化 不对称合成 反应机理 

分 类 号：O62[理学—有机化学]