辐照型钼锝发生器制备技术研究  

Research on the Preparation of Irradiated-type^(99)Mo-^(99m)Tc Generator

作　　者：顾思维 罗宁[1,2,3] 李波[1,2,3] 李沁芝 胡映江[1,2,3] 陈云明[1,2,3] 张劲松 GU Siwei;LUO Ning;LI Bo;LI Qinzhi;HU Yingjiang;CHEN Yunming;ZHANG Jinsong(Nuclear Power Institute of China,Chengdu 610005,China;National Engineering Research Center of Isotope and Pharmaceutical,Chengdu 610213,China;Sichuan Engineering Research Center of Radioactive Isotope,Chengdu 610213,China)

机构地区：[1]中国核动力研究设计院,成都610005 [2]同位素及药物国家工程研究中心,成都610213 [3]四川省放射性同位素工程技术研究中心,成都610213

出　　处：《同位素》2024年第3期237-244,共8页Journal of Isotopes

基　　金：核能开发科研项目(碘-131、碘-125、钼-99、镥-177、镭-223、铼-188的反应堆辐照规模化生产工艺研究)。

摘　　要：针对裂变型^(99)Mo-^(99m)Tc发生器的原料^(99)Mo供应不稳定以及凝胶型^(99)Mo-^(99m)Tc发生器的生产时间长等问题,将凝胶颗粒的合成工艺流程提前至反应堆辐照前,利用真空冷冻干燥技术制备一种以钼[^(99)Mo]酸钛为柱填料的辐照型^(99)Mo-^(99m)Tc发生器。通过研究分析原料的类型、钼钛摩尔比、干燥方式等条件对辐照型^(99)Mo-^(99m)Tc发生器性能的影响,优化了钼[^(99)Mo]酸钛凝胶颗粒的制备工艺,制得了新型辐照型^(99)Mo-^(99m)Tc发生器。在连续七次淋洗过程中发现,淋洗液的pH为5.0~6.0,高锝[^(99m)Tc]酸钠溶液的核纯度≥99.92%,淋洗效率≥72.07%,放化纯度≥98.8%,钛含量<1μg/mL,淋洗峰位于2~4 mL,无拖尾现象,制备的辐照型^(99)Mo-^(99m)Tc发生器的性能优异。该工艺简化了放射性操作工艺流程,缩短了放射性操作时长,减小了制备过程中^(99)Mo的衰变损失,并且提高了发生器淋洗效率。Due to the excellent nuclear properties,^(99m)Tc has been used in the field of early diagnosis of tumor and nuclear medicine imaging.As the most widely applied radioisotope,it accounts for more than 70%of the market of total radioisotopes used in the nuclear medicine diagnosis.Until now,^(99m)Tc in clinical has been prepared by the^(99)Mo-^(99m)Tc generators.To improve the disadvantages of current technologies including unstable supplement of the fission^(99)Mo for the fission-type^(99)Mo-^(99m)Tc generator and long production time for the gel-type^(99)Mo-^(99m)Tc generator,a new irradiatedtype^(99)Mo-^(99m)Tc generator filled with the Ti^(99)Mo has been developed.The effects of the chemical agents,Mo:Ti molar ratio,dry methods on the elution properties of the Ti^(99)Mo-based^(99)Mo-^(99m)Tc generator were investigated.Based on the results of simulation experiments and performance tests,the elution from the irradiated-type^(99)Mo-^(99m)Tc generator was found to be accorded with medical standard.During the seven elution processes,the radionuclidic purity of sodium technetium-99m solution was above 99.92%,the radiochemical purity was higher than 98.8%,the pH value was between 5.0 and 6.0 and the average elution efficiency reached 72.07%,the peak of elute curve was located at 2-4 mL without the phenomenon of trailing,showing the excellent performance.The synthesized preparation has been advanced before the process of irradiation by the reactor,to simplify the operational radioactive procedures,shorten the production time,increase the elution efficiency of the generator and decrease the loss of^(99)Mo decay.

关 键 词：^(99m)Tc 辐照型^(99)Mo-^(99m)Tc发生器 钼[^(99)Mo]酸钛 真空冷冻干燥 

分 类 号：TL92[核科学技术—核燃料循环与材料] TL99