Efficacy and Safety of Traditional Chinese Patent Medicine Qizhi Weitong Granules(气滞胃痛颗粒)in Irritable Bowel Syndrome with Predominant Constipation:A Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials  

作　　者：曹增 陶紫晶 蒋天媛 刘倩 牛然 张格知 杨洋 魏玮 CAO Zeng;TAO Zi-jing;JIANG Tian-yuan;LIU Qian;NIU Ran;ZHANG Ge-zhi;YANG Yang;WEI Wei(Department of Gastroenterology,Wangjing Hospital,China Academy of Chinese Medical Sciences·Beijing Key Laboratory of TCM Diagnosis of Functional Gastrointestinal Diseases,BZ0374,Beijing 100102,China)

机构地区：[1]Department of Gastroenterology,Wangjing Hospital,China Academy of Chinese Medical Sciences·Beijing Key Laboratory of TCM Diagnosis of Functional Gastrointestinal Diseases,BZ0374,Beijing 100102,China

出　　处：《World Journal of Integrated Traditional and Western Medicine》2023年第4期13-20,共8页世界中西医结合杂志（英文）

基　　金：supported by National Natural Science Foundation of China:International (regional)cooperation and exchange project (81820108033);China Academy of Chinese Medical Sciences Youth Talent Project (ZZ14-YQ-020)。

摘　　要：Objective:To systematically review the efficacy and clinical safety of Qizhi Weitong Granules(气滞胃痛颗粒)(QZWT)in the treatment of irritable bowel syndrome with predominant constipation(IBS-C).Methods:Randomized controlled trials(RCTs)of QZWT in patients with IBS-C were retrieved from Pub Med,EMBASE,Cochrane Library,China National Knowledge Infrastructure(CNKI),Wanfang,Chinese Scientific Journals Database(VIP),and Chinese Biological Medical Database(CBM)from inception to December 3,2022.Conventional meta-analysis with random-effects model or fixed-effects model and trial sequential analysis(TSA)were performed by Review Manager 5.4,Stata and TSA software.Results:A total of 4 RCTs and 368 patients with IBS-C were included in this study.The findings of the meta-analysis indicated that the cure and efficacy rate of the experimental group was significantly higher than that of the control group[RR=2.19;(95%CI,1.35–3.55),P<0.01;RR=1.14;(95%CI,1.03–1.27),P<0.05],while the result of Bristol Score was negative.The funnel plot was probably symmetry,and the P value was>0.05 in the Egger test,which confirmed the nonexistence of significant publication bias in this outcome.TSA showed the cumulative z-value crossed the traditional threshold and TSA threshold,while it didn't get to the required information size.Finally,2 studies reported adverse events after QZWT treatment,including 3 cases of diarrhea.No serious adverse events were reported.Conclusion:QZWT was an effective and safe complementary therapy in the treatment of IBS-C with no obvious adverse reactions.TSA analysis confirmed our meta-analysis results.Therefore,QZWT may be a potential candidate for the treatment of IBS-C.However,due to the limited quality of current studies,more long-term,randomized,double-blinded clinical trials are needed in future studies.

关 键 词：Qizhi Weitong Granules(气滞胃痛颗粒) Irritable bowel syndrome with predominant Constipation META-ANALYSIS Trial sequential analysis Chinese patent medicine 

分 类 号：R285.6[医药卫生—中药学]