观察加味当归四逆汤联合西药改善心力衰竭(心肾阳虚证)患者睡眠质量的效果  

Study on the Effect of Modified Danggui Sini Tang Combined with Western Medicine on Improving Sleep Quality in Patients with Heart Failure(Heart and Kidney Yang Deficiency Syndrome)

作　　者：陈垦 CHEN Ken(Changle District Second Hospital,Fuzhou 360211,China)

机构地区：[1]福州市长乐区第二医院,福州360211

出　　处：《世界睡眠医学杂志》2024年第4期755-757,761,共4页World Journal of Sleep Medicine

摘　　要：目的:综合分析心力衰竭(心肾阳虚证)患者采用加味当归四逆汤联合西药治疗的疗效及对睡眠质量的效果。方法:选取2022年8月至2023年8月福州市长乐区第二医院收治的心力衰竭(心肾阳虚证)患者90例作为研究对象,按照随机数字表法分为对照组和观察组,每组45例。对照组给予西药治疗,观察组在对照组基础上联合给予加味当归四逆汤治疗。采用匹兹堡睡眠质量指数(PSQI)评估2组患者的睡眠质量,比较2组患者不良反应的发生情况,并对2组的多导睡眠图(PSG)指标进行比较,包括总睡眠时间(TST)、睡眠效率(SE)、入睡后觉醒(WASO)、Delta睡眠比率(DSR)、快速动眼期(REM)潜伏期。结果:治疗后,观察组PSQI评分显著低于对照组,观察组不良反应发生率显著低于对照组,观察组TST、SE、DSR更高,WASO、REM潜伏期更低,差异均有统计学意义(均P<0.05)。结论:在心肾阳虚心力衰竭患者中,应用加味当归四逆汤联合西药治疗具有显著价值,能够有效改善患者的睡眠质量,预防不良反应,从而提高整体预后水平,值得临床推广应用。Objective:To comprehensively analyze the therapeutic effect and sleep quality of modified Danggui Sini Tang combined with Western medicine in patients with heart failure(heart and kidney yang deficiency syndrome).Methods:A total of 90 patients with heart failure(heart and kidney yang deficiency syndrome)admitted to the Second Hospital of Changle District,Fuzhou City from August 2022 to August 2023 were selected as the study subjects.Using a random number table method,they were randomly divided into control and observation groups,with 45 cases in each group.The control group was treated with Western medicine,while the observation group was treated with modified Danggui Sini Tang in combination with the control group.The Pittsburgh Sleep Quality Index(PSQI)was used to evaluate the sleep quality of two groups of patients,compare the occurrence of adverse reactions,and compare the polysomnography(PSG)indicators of the two groups,including total sleep time(TST),sleep efficiency(SE),wakefulness after sleep(WASO),Delta sleep ratio(DSR),and rapid eye movement(REM)latency.Results:After treatment,the PSQI score of the observation group was significantly lower than that of the control group,and the incidence of adverse reactions in the observation group was significantly lower than that of the control group.The TST,SE,DSR,WASO,and REM latency were higher in the observation group,and the difference between the two groups was statistically significant(P<0.05).Conclusion:In patients with heart and kidney yang deficiency and heart failure,the use of modified Danggui Sini Tang combined with Western medicine treatment has significant value.It can effectively improve the patient's sleep quality,prevent adverse reactions,and thus improve the overall prognosis level,which is worthy of clinical promotion and application.

关 键 词：心力衰竭 加味当归四逆汤 西药 心肾阳虚证 睡眠质量 中西医结合 心血管疾病 

分 类 号：R541.61[医药卫生—心血管疾病] R338.63[医药卫生—内科学]